A Novel Non-cationic Lipid-polymer-based Nanossembly for the Complexation and Intracellular Delivery of Nucleic Acids
S. Thai Thayumanavan, Ph.D.
- Non-cationic lipid-polymer-nucleic acid nanoassembly for efficient delivery of nucleic-acid-based therapeutics such as siRNAs
- Non-cationic nucleic acid delivery system that mitigates carrier associated cytotoxicity
- Symbiotic, self-assembled delivery system with high nucleic acid encapsulation efficiency
- Capable of triggered cytosolic release of the encapsulated nucleic acids upon intracellular delivery
- Biocompatible surface and stable against degradation by nucleases
- Tunable cargo release rates
This invention provides a symbiotic and non-cationic nanoassembly of lipids, polymers and nucleic acid molecules for efficient encapsulation, delivery and triggered release of nucleic-acid-based therapeutics.
Dr. Thayumanavan is a Professor in the Department of Chemistry. He is a highly accomplished expert in organic and polymer chemistry and a prolific inventor. His research focuses on the design, synthesis and characterization of organic macromolecules of interest in supramolecular chemistry, materials science and biological applications. Dr. Thayumanavan has broad and well-established expertise in developing custom-designed molecules for specific end-use applications such as pharmaceutical delivery, smart sensors, and fuel cells.
Available for Licensing and/or Sponsored Research
UMA 19-048
Patent Issued
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