Polymeric Nanogles for the Encapsulation, Delivery and pH-Triggered Release of Proteins
S. Thai Thayumanavan, Ph.D.
- Nanogel encapsulated protein therapeutics for the treatment of lysosomal storage diseases
- Nanogel encapsulated diagnostic, imaging or sensing agents
- Stably encapsulated proteins that are not prone to proteolytic degradation when being delivered to the target site
- Controlled release of the protein cargo at a pH that is commensurate with the lysosomal pH
This invention provides a new class of polymeric nanogels that are capable of encapsulating protein molecules and releasing them when pH decreases to a level that is commensurate with the lysosomal pH. The nanogels can be used to deliver enzymes for the treatment of lysosomal storage diseases.
Dr. Thayumanavan is a Professor in the Department of Chemistry. He is a highly accomplished expert in organic and polymer chemistry and a prolific inventor. His research focuses on the design, synthesis and characterization of organic macromolecules of interest in supramolecular chemistry, materials science and biological applications. Dr. Thayumanavan has broad and well-established expertise in developing custom-designed molecules for specific end-use applications such as pharmaceutical delivery, smart sensors, and fuel cells.
Available for Licensing and/or Sponsored Research
UMA 15-013
U.S. Patent US 10,617,652 Issued
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