Stable, Biocompatible and “Green” Protein Films for Antifouling, Antimicrobial and Tissue Engineering Applications
Vincent M. Rotello, Ph.D.
• Antimicrobial catheters
• Implantable biomedical devices having antifouling coatings
• Antifouling coatings for marine equipment
• Drug-releasing antimicrobial films or coatings for wound healing or in-dwelling devices
• Protein films or coatings for directed cell adhesion and growth and for tissue engineering
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PERFORMANCE FACTORS
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Known Chemically Crosslinked Protein Films
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THIS INVENTION
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Environment-Friendly Fabrication Process
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Free of Unwanted Additives
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Biocompatible and Degradable by Design
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Directed Cell Adhesion, Alignment and Growth
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This invention provides protein films or coatings for antifouling, antimicrobial and tissue engineering applications, and scalable, environment-friendly methods for fabricating the films. The films are water-stable, biocompatible and resistant to protein and bacterial fouling, and can be made to direct human cell adhesion, alignment and growth. The films can be fabricated on both hard and flexible substrates, and the fabrication process does not involve the use of environmentally hazardous materials such as organic solvents or chemical crossslinkers. The biodegradability of the films can be tuned to enable controlled release of functional or therapeutic agents.
Dr. Rotello is the Charles A. Goessmann Professor of Chemistry at the University of Massachusetts Amherst. His research team focuses on creating new functional materials for a variety of applications.
Available for Licensing and/or Sponsored Research
UMA 15-016
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Patent Issued
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