Novel Small Molecule Inhibitors of Caspase-6
Jeanne Hardy, Ph.D.
- Novel small molecule drug candidates for the treatment of Alzheimer’s and Huntington’s diseases
- Novel compositions of matter
- Small molecule compounds
- High caspase selectivity and specificity for caspase-6
Caspase-6 is a drug target for Alzheimer’s and Huntington’s diseases. This invention provides novel small molecule inhibitors of caspase-6. The lead compound exhibited superior caspase selectivity and specificity for caspase-6, and has an IC50 of 33 nM.
Dr. Jeanne Hardy is a Professor in the Department of Chemistry at UMass Amherst. Her research group aims to understand and exploit allosteric regulation of proteases by designing allosteric binding sites for alternative small molecules, and designs novel drug-like compounds that target allosteric sites and exosites in protease drug targets.
Available for Licensing and/or Sponsored Research
UMA 18-035
Patent Issued and Patent Pending
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