Let-7 promotes superior anti-tumor activity of CD8 T cells and memory formation
This invention demonstrates that let-7 miRNA regulates T cell responses and offers a strategy in developing next-generation immunotherapies by preserving the multipotency of effector cells rather than enhancing the efficacy of differentiation.
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Localization of Payload Delivery Systems to Tumor Sites via Beacon Cell Targeting
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Noncationic Nucleic Acid-Polymer Complexes for Nucleic Acid Delivery
This invention provides a new strategy for nucleic acid delivery by using novel cross-linkable and surface-charge modifiable synthetic polymers. The use of the novel polymer system allows for robust nuclecid-polymer complexation, easy removal of cationic moieties of the polymer and self-crosslinking of the polymer in a single step, and stimuli-responsive release of the nucleic acid molecules in the cell.
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Cell-Membrane-Coated Polymeric Nanoparticles for Selective Intracellular Delivery of Therapeutics
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Novel Ferroptosis Inducing Compounds as Anti-cancer Agents
Ferroptosis is a well-defined cell death mechanism distinct from other regulated cell death phenotypes such as apoptosis, necrosis and autophagy. This invention provides novel ferroptosis inducer compounds that represent a new class of highly specific chemotherapeutic agents.
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Demineralized Bone Paper and Applications Thereof
This invention provides structurally well-defined, three-dimensional bone tissue grafts produced from stacked demineralized bone paper (DBP), methods for treating a subject using such bone tissue grafts, methods for making DBP, and in vitro assay systems and methods for assaying the effect of an agent on bone development or health.
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Polymeric Nanoparticle-Based Antibiofilm Therapy
This invention provides a novel therapeutic platform to combat multidrug-resistant bacterial and biofilm infections using engineered polymeric nanoparticles. The polymeric nanoparticles can penetrate and eradicate pre-formed bacterial biofilms while maintaining high therapeutic indices. The nanoparticles are formed via self-assembly of engineered synthetic polymers in aqueous solutions, without the need to use any organic solvent or purification procedures.
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An Ex Vivo Method of Generating Super Regulatory T Cells as a Cell-based Therapy for the Prevention of Graft-vs-Host Disease
Regulatory T cells maintain immunological tolerance and dampen inflammatory responses. Administering regulatory T cells can prevent the immune-mediated tissue destruction of graft-versus-host disease, which frequently accompanies hematopoietic stem cell transfer. This technology provides a simple and effective method to generate and expand a unique population of stable and highly suppressive regulatory T cells, which can be used as a cell-based therapy for the prevention of graft-versus-host disease.
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Novel Small Molecule Inhibitors of Caspase-6
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A Novel Non-cationic Lipid-polymer-based Nanossembly for the Complexation and Intracellular Delivery of Nucleic Acids
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