The University of Massachusetts Amherst

Search Results - Therapeutics+%26+prevention

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Let-7 promotes superior anti-tumor activity of CD8 T cells and memory formation
Published: 4/29/2024   |   Inventor(s): Leonid Pobezinsky, Elena Pobezinskaya
Category(s): Biotechnology, Life Sciences, Therapeutics & prevention, Research tools
Localization of Payload Delivery Systems to Tumor Sites via Beacon Cell Targeting
Published: 3/1/2024   |   Inventor(s): Neil Forbes, Nele Van Dessel, John Klier, Shane Taylor, Vishnu Raman
Category(s): Biotechnology, Healthcare, Life Sciences, Therapeutics & prevention
Noncationic Nucleic Acid-Polymer Complexes for Nucleic Acid Delivery
Published: 10/26/2023   |   Inventor(s): Sankaran Thayumanavan
Category(s): Biotechnology, Healthcare, Nanotechnology, Life Sciences, Therapeutics & prevention
Cell-Membrane-Coated Polymeric Nanoparticles for Selective Intracellular Delivery of Therapeutics
Published: 8/10/2023   |   Inventor(s): Sankaran Thayumanavan
Category(s): Healthcare, Life Sciences, Biotechnology, Nanotechnology, Therapeutics & prevention, Research tools
Novel Ferroptosis Inducing Compounds as Anti-cancer Agents
Ferroptosis is a well-defined cell death mechanism distinct from other regulated cell death phenotypes such as apoptosis, necrosis and autophagy. This invention provides novel ferroptosis inducer compounds that represent a new class of highly specific chemotherapeutic agents.
Published: 8/10/2023   |   Inventor(s): Rachid Skouta, Thomas Dawson, Rohit Bhadoria
Category(s): Chemicals, Healthcare, Life Sciences, Research tools, Therapeutics & prevention
Demineralized Bone Paper and Applications Thereof
This invention provides structurally well-defined, three-dimensional bone tissue grafts produced from stacked demineralized bone paper (DBP), methods for treating a subject using such bone tissue grafts, methods for making DBP, and in vitro assay systems and methods for assaying the effect of an agent on bone development or health.
Published: 8/10/2023   |   Inventor(s): Jungwoo Lee, Jae-Hyuck Shim, Ryan Carpenter, Yongkuk Park, Jun-Goo Kwak
Category(s): Biotechnology, Devices, Healthcare, Life Sciences, Research tools, Therapeutics & prevention
Polymeric Nanoparticle-Based Antibiofilm Therapy
This invention provides a novel therapeutic platform to combat multidrug-resistant bacterial and biofilm infections using engineered polymeric nanoparticles. The polymeric nanoparticles can penetrate and eradicate pre-formed bacterial biofilms while maintaining high therapeutic indices. The nanoparticles are formed via self-assembly of engineered synthetic polymers in aqueous solutions, without the need to use any organic solvent or purification procedures.
Published: 8/10/2023   |   Inventor(s): Vincent Rotello, Ryan Landis, Akash Gupta
Category(s): Healthcare, Life Sciences, Biotechnology, Therapeutics & prevention
An Ex Vivo Method of Generating Super Regulatory T Cells as a Cell-based Therapy for the Prevention of Graft-vs-Host Disease
Regulatory T cells maintain immunological tolerance and dampen inflammatory responses. Administering regulatory T cells can prevent the immune-mediated tissue destruction of graft-versus-host disease, which frequently accompanies hematopoietic stem cell transfer. This technology provides a simple and effective method to generate and expand a unique population of stable and highly suppressive regulatory T cells, which can be used as a cell-based therapy for the prevention of graft-versus-host disease.
Published: 10/3/2023   |   Inventor(s): Lisa Minter, Gregory Tew, Emrah Ozay
Category(s): Biotechnology, Healthcare, Life Sciences, Research tools, Therapeutics & prevention
Novel Small Molecule Inhibitors of Caspase-6
Published: 8/10/2023   |   Inventor(s): Jeanne Hardy, Penchala Narasimharao Meka
Category(s): Therapeutics & prevention, Life Sciences, Healthcare
A Novel Non-cationic Lipid-polymer-based Nanossembly for the Complexation and Intracellular Delivery of Nucleic Acids
Published: 10/3/2023   |   Inventor(s): Sankaran Thayumanavan, Kingshuk Dutta
Category(s): Biotechnology, Healthcare, Life Sciences, Nanotechnology, Therapeutics & prevention
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