The University of Massachusetts Amherst

Demineralized Bone Paper and Applications Thereof

LEAD INVENTOR:
Jungwoo Lee, Ph.D.
 
PRODUCT OPPORTUNITIES

•       Three-dimensional, living bone tissue grafts produced from stacked demineralized bone paper (DBP) for clinical applications

•       DBP-based high-throughput and high-content assay systems for bone disease drug discovery

•       Other DBP-containing products such as microfluidic bone marrow chips

 
ADVANTAGES

Three-dimensional, living bone tissue grafts:

•       Have well-defined and personalized shape and structure

•       Can be rapidly generated

•       Can easily incorporate drugs to promote bone tissue regeneration

DBP-based assay systems:

•       High-throughput and high-content

•       Simple and scalable

•       Faithfully mimic the bone tissue remodeling process

•       Can be easily humanized with human cells and other materials 

 
TECHNOLOGY DESCRIPTION
This invention provides structurally well-defined, three-dimensional bone tissue grafts produced from stacked demineralized bone paper (DBP), methods for treating a subject using such bone tissue grafts, methods for making DBP, and in vitro assay systems and methods for assaying the effect of an agent on bone development or health.
ABOUT THE LEAD INVENTOR
Dr. Jungwoo Lee is an Associate Professor in the Department of Chemical Engineering and a BME Adjunct at the University of Massachusetts Amherst. His research focuses on translational biomaterials, bone marrow tissue engineering, microenvironment aging and cancer, and biomedical imaging.
AVAILABILITY:
Available for Licensing and/or Sponsored Research
DOCKET:
UMA 20-046
PATENT STATUS:
Patent Pending
Contact:
Nikki Hoang
Licensing Officer
University of Massachusetts
nikkihoang@research.umass.edu
Inventor(s):
Jungwoo Lee
Jae-Hyuck Shim
Ryan Carpenter
Yongkuk Park
Jun-Goo Kwak
Keywords: