Demineralized Bone Paper and Applications Thereof
Jungwoo Lee, Ph.D.
• Three-dimensional, living bone tissue grafts produced from stacked demineralized bone paper (DBP) for clinical applications
• DBP-based high-throughput and high-content assay systems for bone disease drug discovery
• Other DBP-containing products such as microfluidic bone marrow chips
Three-dimensional, living bone tissue grafts:
• Have well-defined and personalized shape and structure
• Can be rapidly generated
• Can easily incorporate drugs to promote bone tissue regeneration
DBP-based assay systems:
• High-throughput and high-content
• Simple and scalable
• Faithfully mimic the bone tissue remodeling process
• Can be easily humanized with human cells and other materials
This invention provides structurally well-defined, three-dimensional bone tissue grafts produced from stacked demineralized bone paper (DBP), methods for treating a subject using such bone tissue grafts, methods for making DBP, and in vitro assay systems and methods for assaying the effect of an agent on bone development or health.
Dr. Jungwoo Lee is an Associate Professor in the Department of Chemical Engineering and a BME Adjunct at the University of Massachusetts Amherst. His research focuses on translational biomaterials, bone marrow tissue engineering, microenvironment aging and cancer, and biomedical imaging.
Available for Licensing and/or Sponsored Research
UMA 20-046
F
Patent Pending
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