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This invention provides structurally well-defined, three-dimensional bone tissue grafts produced from stacked demineralized bone paper (DBP), methods for treating a subject using such bone tissue grafts, methods for making DBP, and in vitro assay systems and methods for assaying the effect of an agent on bone development or health.

Regulatory T cells maintain immunological tolerance and dampen inflammatory responses. Administering regulatory T cells can prevent the immune-mediated tissue destruction of graft-versus-host disease, which frequently accompanies hematopoietic stem cell transfer. This technology provides a simple and effective method to generate and expand a unique population of stable and highly suppressive regulatory T cells, which can be used as a cell-based therapy for the prevention of graft-versus-host disease.

This invention provides devices and methods for the interrogation of molecular structure and function of virtually any biological tissue  by allowing histological analyses of large biological tissues with numerous biomarkers (antibodies, RNAs, chemical labels). In addition, this technique maintains the integrity of large tissue samples making it possible to perform multiple rounds of histological staining to resolve 3-D organization of biological structures at the macroscopic and microscope scale.

This invention demonstrates that let-7 miRNA  regulates T cell responses and offers a strategy in developing next-generation immunotherapies by preserving the multipotency of effector cells rather than enhancing the efficacy of differentiation.

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This invention provides OmpG nanopore-based sensors for antibody screening applications. Each OmpG nanopore is engineered to contain a heterologous peptide sequence in one or more flexible loops of the nanopore, allowing for target-specific binding and detection.

This invention provides economical, bio-interactive surfaces and surface treatment methods for selective capture of targeted epithelial cells or other cell types from cell mixtures or complex biological fluids. Preparation or fabrication of the engineered surfaces provided by this technology does not require the use of expensive and unstable biomolecular materials, and the resulting surfaces can distinguish different cell types or cells that express different levels of the same surface adhesion marker. Such engineered surfaces can be used as economical tools for assessment of cancer risk, cancer diagnosis, and tracking of the effectiveness of cancer treatments, among other potential applications.

Character rigging is the process where animators fit a skeleton to a 3D model, which then allows the animators to manipulate the movement of, or animate, the model. Currently, animators must manually define the skeleton’s joints, how they’re connected, and how the model’s body parts move. This is a very time intensive process that can take hours or days just for a single character. With the rapid rise in need for animation-ready characters and avatars in the areas of games, films, mixed reality and social media, character rigging is presently a major bottleneck to scaling the creation of animated characters.

 

In this work, the authors have written software called RigNet, which is an end-to-end automated method for producing animation rigs from input character models. By automating character rigging through RigNet, the character rigging process time is reduced from hours to minutes. RigNet is based on a deep learning architecture, trained on a large and diverse collection of rigged models, including their mesh, skeletons and corresponding skin weights. RigNet is able to predict both a unique skeleton and a skinning that match animator expectations, which is in contrast to prior art methods that just fit pre-defined, template skeletons to the 3D models that aren’t high enough quality. Finally, because all that is needed to use RigNet is a 3D model, animators do not need to be trained experts to rig characters, as is the case today.