The University of Massachusetts Amherst

Search Results - therapeutics+%26+prevention

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Amphiphilic Polymer Capsules and Related Methods of Interfacial Assembly
A chemical crosslinking process is used to prepare capsules from PEGylated polyolefins using either oil-in-water (i.e., oil inside the capsule in a water-based system), or water-in-oil system. The covalent network structure of these capsules make them more robust than many other systems under investigation in controlled-release.The unique nature of the crosslinking chemistry is such that the crosslinks can be made either hydrolytically stable or unstable. Those with hydrolytically stable crosslinks have longer carrier lifetimes, while those with hydrolytically unstable crosslinks will degrade over a time period that can be controlled by crosslink density and the type of crosslinker used.
Published: 6/11/2021   |   Inventor(s): Todd Emrick, Kurt Breitenkamp
Category(s): Material science, Therapeutics & prevention, Biotechnology
Nature-Inspired Nanosponges as Antibacterial and Antifungal Agents
This invention provides nature-inspired nanosponges capable of penetrating and eradicating bacterial biofilms and eliminating drug-resistant fungi. The nanosponges are nanoparticles composed of antimicrobial essential oil and crosslinked gelatin, and can be used in a wide-variety of antibacterial and antifungal applications.
Published: 5/17/2021   |   Inventor(s): Vincent Rotello, Ryan Landis
Category(s): Food technology & plant science, Life Sciences, Environmental, Healthcare, Nanotechnology, Therapeutics & prevention
Polymeric Nanoparticle-Based Antibiofilm Therapy
This invention provides a novel therapeutic platform to combat multidrug-resistant bacterial and biofilm infections using engineered polymeric nanoparticles. The polymeric nanoparticles can penetrate and eradicate pre-formed bacterial biofilms while maintaining high therapeutic indices. The nanoparticles are formed via self-assembly of engineered synthetic polymers in aqueous solutions, without the need to use any organic solvent or purification procedures.
Published: 5/14/2021   |   Inventor(s): Vincent Rotello, Ryan Landis, Akash Gupta
Category(s): Healthcare, Life Sciences, Biotechnology, Therapeutics & prevention
Noncationic Nucleic Acid-Polymer Complexes for Nucleic Acid Delivery
Published: 5/11/2021   |   Inventor(s): Sankaran Thayumanavan
Category(s): Biotechnology, Healthcare, Nanotechnology, Life Sciences, Therapeutics & prevention
An Ex Vivo Method of Generating Super Regulatory T Cells as a Cell-based Therapy for the Prevention of Graft-vs-Host Disease
Regulatory T cells maintain immunological tolerance and dampen inflammatory responses. Administering regulatory T cells can prevent the immune-mediated tissue destruction of graft-versus-host disease, which frequently accompanies hematopoietic stem cell transfer. This technology provides a simple and effective method to generate and expand a unique population of stable and highly suppressive regulatory T cells, which can be used as a cell-based therapy for the prevention of graft-versus-host disease.
Published: 1/28/2021   |   Inventor(s): Lisa Minter, Gregory Tew, Emrah Ozay
Category(s): Biotechnology, Healthcare, Life Sciences, Research tools, Therapeutics & prevention
Novel Small Molecule Inhibitors of Caspase-6
Published: 7/2/2020   |   Inventor(s): Jeanne Hardy, Penchala Narasimharao Meka
Category(s): Therapeutics & prevention, Life Sciences, Healthcare
A Novel Non-cationic Lipid-polymer-based Nanossembly for the Complexation and Intracellular Delivery of Nucleic Acids
Published: 12/20/2019   |   Inventor(s): Sankaran Thayumanavan, Kingshuk Dutta
Category(s): Biotechnology, Healthcare, Life Sciences, Nanotechnology, Therapeutics & prevention
Novel Polymeric Nanogels for Controlled Intracellular Protein Delivery and Traceless Release
Published: 9/18/2019   |   Inventor(s): Sankaran Thayumanavan, Jiaming Zhuang
Category(s): Life Sciences, Biotechnology, Healthcare, Research tools, Therapeutics & prevention, Nanotechnology, Diagnostic technology
Novel Enzymatic Methods for Generating High-Yield, Ultrapure and Nonimmunogenic RNA
RNA is increasingly used as both a research and therapeutic tool to control gene expression. Currently, there are two established routes to generate synthetic RNA: chemically or enzymatically. While the chemical route is limited to RNAs shorter than about 30 nucleotide residues in length, the enzymatic route is routinely used to generate large quantities of short and long RNA in vitro using T7 RNA polymerase or one of its closely related family members. The enzymatic method, however, often generates undesired longer RNA products that could invoke unwanted immune responses in vivo. This invention provides novel enzymatic methods for generating high yields, ultrapure and non-immunogenic RNA.
Published: 9/16/2019   |   Inventor(s): Craig Martin, Elvan Cavac, Kithmie MalagodaPathiranage
Category(s): Research tools, Biotechnology, Healthcare, Life Sciences, Therapeutics & prevention
Hyaluronic Acid Based Nanogel or Microgel Compositions for Targeted Delivery of Small Molecule Therapeutics
Published: 9/13/2019   |   Inventor(s): Sankaran Thayumanavan, Lisa Minter
Category(s): Biotechnology, Diagnostic technology, Healthcare, Life Sciences, Nanotechnology, Research tools, Therapeutics & prevention
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