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Water-Soluble Temozolomide Derivatives and Polymer-Temozolomide Conjugates for Enhanced Glioblastoma Treatment
This invention provides novel compositions of water-soluble small molecule temozolomide derivatives and water-soluble polymer-temozolomide conjugates for enhanced treatment of glioblastoma multiforme.
Published: 5/9/2018   |   Inventor(s): Todd Emrick, Matthew Skinner
Category(s): Therapeutics & prevention, Life Sciences, Healthcare
WearID: RFID Wristband Reader
Advances in RFID technology are opening up a myriad of commercial applications related to identifying and interacting with objects, from home automation and health and wellness to augmented reality and tele-rehabilitation. Passive UHF RFID readers are a particularly attractive option due to their low cost and no maintenance; however, their limited range necessitates the use of many readers to cover a single large room, an expensive and labor-intensive process.

This invention, known as WearID, overcomes the traditional limitations of UHF RFID readers through end-to-end design innovation, optimizing the wearable reader for low power, form-factor, and performance. WearID is able to detect grasping, releasing, touching, and passing near tagged objects.

Published: 5/2/2018   |   Inventor(s): Deepak Ganesan, Ali Kiaghadi, Pan Hu, Jeremy Gummeson
Category(s): Devices & sensors, Communications & internet, Electronics, Engineering, Software & information technology, Healthcare
EyeFrame: Real-time domain-general multitasking assistance
Though many paradigms have been developed to study multitasking using eye tracking, most traditional applications of eye tracking are not used in real time, but instead to augment training or simply to observe optimal strategies. As eye tracking methods become more popular, they have been applied in the field of human-computer interaction and usability, as well as human-robot interaction. Recent real-time eye tracking assistance systems have focused on specific domains such as training, evaluation, or basic hypothesis testing in areas such as medical imaging, security, and aviation.

 

EyeFrame successfully addresses the need for domain-general multitasking assistance. EyeFrame allows the user to program sensory cues on a screen display which direct the user’s attention to neglected areas of the screen. These neglected areas are determined from real-time attention data gathered by an input device, such as a mouse or an eye tracker. EyeFrame is an assistive system for managing multiple visual tasks, which is domain-general, transparent, intuitive, non-interfering, non-command, improves control (without replacing direct control), and adaptively extrapolates to a variety of circumstances.

Published: 12/14/2017   |   Inventor(s): Hava Siegelmann, Patrick Taylor
Category(s): Software & information technology, Research tools, Healthcare, Computers
Curcumin Stable Formulations
The spice, turmeric, has many beneficial properties and is widely touted as a treatment for many conditions, e.g. cancer, inflammation, digestive problems. However, the health-boosting component of turmeric, curcumin, degrades rapidly at physiological pH, making it difficult to

develop curcumin-based therapeutics.

 

The invention concerns methods and formulations of curcumin that enhance its stability and bioactivity. Specifically, a series of antioxidants with diverse chemical structures, including gallic acid, ascorbate (vitamin C),tert-butylhydroquinone (tBHQ), coffeic acid, rosmarinic acid, and Trolox (a water-soluble analog of vitamin E), dramatically increase curcumin stability in phosphate buffer. Moreover, the antioxidants significantly increased stability and anti-cancer effects of curcumin in cultured cancer cells and animal models. These practical strategies could be emplyed to increase the stability and bioactivity of curcumin and other dietary phenolic compounds.

Published: 12/14/2017   |   Inventor(s): Guodong Zhang, Eric Decker, Yoshiki Nimiya
Category(s): Food technology & plant science, Healthcare
Pressure Sensitive Adhesives
Pressure sensitive adhesives bond two materials when physical pressure is applied to marry the adhesive with the adherent. They are widely applied in self-adhesive tapes, labels and marking films, medical plasters and pads, dermal pharmaceutical dosage forms, medical drapes and biomedical electrodes. Curing current adhesives often involves UV irradiation or heat, capital and energy intensive steps which may produce to toxic byproducts.

 

The invention concerns novel compositions and crosslinking strategies that greatly simplify fabrication of pressure sensitive adhesives.  A soluble and flowable polymer containing latent crosslinking sites is applied to a substrate as a low-viscosity solution or melt.  After application, spontaneous crosslinking occurs at ambient conditions, eliminating the need for post-crosslinking equipment, capital and expense. It also eliminates formation of undesired or toxic residues; allows the formation of crosslinked adhesive layers on temperature-sensitive substrates; enables the use of opaque crosslinkable adhesive formulations; and facilitates the incorporation of adhesives into porous or complex substrates. These strategies may be generalized to broader classes of solvent borne and hot melt pressure adhesives.

 

Published: 8/14/2017   |   Inventor(s): Shelly Peyton, John Klier, Yen Tran, Todd Emrick
Category(s): Engineering, Healthcare, Material science
Chemically Stable Fibers Electrospun from Polyelectrolytes
The invention is a new platform for fabricating nano- and macro- scale fiber materials and for encapsulation. Complex coacervates are associative complexes of positive and negative polyelectrolytes, which form complexes due to a combination of electrostatic and entropic interactions between the oppositely charged polyions. Due to their aqueous solubility, polyelectrolyte solutions are a good medium for encapsulating small molecules. However, while the concept of polyelectrolyte complexes for a drug delivery system and other applications has seen heightened interest in recent years, significant obstacles and challenges remain both in processing technologies and functionalities of the resulting materials.

 

Electrospinning is an established, versatile, inexpensive and scalable process for creating continuous, nanofibrous mats of non-woven nano-/micro-scale diameter fibers. Electrospun mats hold great promise in biomedical, environmental, and industrial fields.

 

The invention provides novel polymer nanofiber or microfiber mats and methods for their preparation via an aqueous, one-step polyelectrolyte complexation and electrospinning of complex coacervates. The process involves an aqueous medium and no organic solvents and/or strongly acidic or basic condition, resulting in chemically and thermally robust fiber mats. Thus, this process and the resulting materials have tremendous potential as a green processing strategy that can serve as the basis for developing a new class environmentally benign fiber scaffolds for use in applications, such as wound healing, water remediation, catalysis, and food packaging.

 

Published: 8/11/2017   |   Inventor(s): Jessica Schiffman, Sarah Perry, Xiangxi Meng
Category(s): Material science, Healthcare, Engineering
Method of Non-Chromatographic Purification of Monoclonal Antibodies
The potent pharmacodynamics and numerous diagnostics of monoclonal antibodies (mAbs) have led to their extensive use as therapeutic treatments for various cancers and autoimmune disorders, and for diagnostic assays. However, rapid developments in the foundational cell biology and recombinant technology of mAbs have not been matched by progress in downstream purification, a major determinant of mAb cost. 

 

mAb purification, largely reliant on chromatography (e.g. Protein A chromatography), is the principal determinant of drug cost. The present invention generally relates to non-chromatographic purification of mAbs, and particularly, to a method of purification of monoclonal antibodies via selective coacervation with hyaluronic acid. The method separates mAb from unwanted proteins and nucleic acids secreted from mAb-producing hybridoma cells, forming a fluid coacervate from which the mAb is purified. This promising technique may be an effective alternative for Protein A chromatography.

Published: 8/10/2017   |   Inventor(s): Paul Dubin, Rachel Wollacott, Daniel Seeman, Alex Malanowski
Category(s): Biotechnology, Healthcare, Life Sciences, Therapeutics & prevention
Prosthetic Fitment System
An ill-fitting prosthesis can result in discomfort and can compromise mobility and performance. Therefore, there is a strong need for innovative diagnostic tools for quantifying the socket-limb interface during the fitment process. Scientists at UMass Amherst have developed a prosthetic socket fitment tool which applies recently-available high-precision line-of-sight ultrasound transceivers and intuitive visualization software to provide a quantifiable internal measurement of the residual limb and bone movement to a prosthetist during the fitment process. This tool will inform the positioning of socket components to ensure a comfortable fit for the patient.
Published: 9/15/2016   |   Inventor(s): Frank Sup, Andrew Lapre, Michael White
Category(s): Devices, Diagnostic technology, Healthcare, Engineering
Silver Nanoparticles Detection and Analysis in Complex Matrices
Silver nanoparticles (AgNPs) are the most commonly used nanoparticles in many consumer products and related matrices. Given the wide application and formation of AgNPs, the environmental and biological fate and toxicity of the AgNPs needs to investigated comprehensively, including if AgNPs transfer through different trophic levels and impact food chains. This invention was developed by combining hydrophobization-mediated extraction with unique capability of Surface-enhanced Raman spectroscopy (SERS).
Published: 9/13/2016   |   Inventor(s): Lili He, Baoshan Xing, Huiyuan Guo
Category(s): Devices, Diagnostic technology, Environmental, Healthcare, Engineering, Nanotechnology
Baterial Detection Platform
This invention invention is a bacterial detection platform integrating sensitive surface-enhanced Raman Scattering (SERS) capabilities and advanced mapping technique that generates detailed chemical images based on a sample’s Raman spectrum. The identification is based on the fingerprint of the bacterial SERS spectra.  The quantification of the cells will be based on the mapping technique
Published: 9/13/2016   |   Inventor(s): Lili He
Category(s): Diagnostic technology, Food technology & plant science, Environmental, Healthcare, Nanotechnology
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