The University of Massachusetts Amherst

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A Novel Treatment Facilitates Blastocyst Hatching
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Published: 3/12/2026   |   Inventor(s): Jesse Mager, Xinjian He
Category(s): Biotechnology, Healthcare, Veterinary science
Cell-Membrane-Coated Polymeric Nanoparticles for Selective Intracellular Delivery of Therapeutics
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Published: 3/9/2026   |   Inventor(s): Sankaran Thayumanavan
Category(s): Healthcare, Life Sciences, Biotechnology, Nanotechnology, Therapeutics & prevention, Research tools
Kulkarni/ Sprayable polymeric scaffold loaded with inflammasome-inhibiting lipid nanorods for anti-inflammatory therapy
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Published: 12/24/2025   |   Inventor(s): Ashish Kulkarni, Dhanashree Surve
Category(s): Healthcare, Material science, Nanotechnology, Therapeutics & prevention, Life Sciences
A lightweight wearable electrode array for electrooculography
Tracking eye movement is integral for constructing virtual reality headsets, and in the healthcare sector, eye movement tracking is useful for diagnosing sleep disorders. Current iterations of commercial eye trackers mainly rely on visually tracking the wearer’s retina using head-mounted cameras. This approach suffers from many analytical limitations, in addition to the fact that the resulting headsets are heavy, cumbersome, and constricting.

 

Aside from cameras, another method to track eye movement is electrooculography (EoG), in which the electric pulses created by the seven extraocular muscles are detected by a skin-mounted electrode. While EoG is the most sensitive and error-free approach to track eye motion, a fully-integrated and portable EoG headset with five electrode leads is not known.

 

Here, Professors Trisha Andrew and Deepak Ganesan create a lightweight garment that can record EoG signals and, therefore, track the eye motions of the wearer. The PIs decorate a lightweight molded-foam sleeping mask with dry electrodes, and integrate a power source and processing circuit onto the headband of the sleep mask. This creates a fully-integrated and sensitive eye tracking system that can be used to create next-generation VR headsets and track eye movement in patients suffering from sleep disorders.

Published: 10/30/2025   |   Inventor(s): Deepak Ganesan, Trisha Andrew, Ali Kiaghadi, Seyedeh Zohreh Homayounfar, Soha Rostaminia
Category(s): Devices & sensors, Healthcare, Material science
Demineralized Bone Paper and Applications Thereof
This invention provides structurally well-defined, three-dimensional bone tissue grafts produced from stacked demineralized bone paper (DBP), methods for treating a subject using such bone tissue grafts, methods for making DBP, and in vitro assay systems and methods for assaying the effect of an agent on bone development or health.
Published: 12/19/2025   |   Inventor(s): Jungwoo Lee, Jae-Hyuck Shim, Ryan Carpenter, Yongkuk Park, Jun-Goo Kwak
Category(s): Biotechnology, Devices, Healthcare, Life Sciences, Research tools, Therapeutics & prevention
An Ex Vivo Method of Generating Super Regulatory T Cells as a Cell-based Therapy for the Prevention of Graft-vs-Host Disease
Regulatory T cells maintain immunological tolerance and dampen inflammatory responses. Administering regulatory T cells can prevent the immune-mediated tissue destruction of graft-versus-host disease, which frequently accompanies hematopoietic stem cell transfer. This technology provides a simple and effective method to generate and expand a unique population of stable and highly suppressive regulatory T cells, which can be used as a cell-based therapy for the prevention of graft-versus-host disease.
Published: 9/25/2025   |   Inventor(s): Lisa Minter, Gregory Tew, Emrah Ozay
Category(s): Biotechnology, Healthcare, Life Sciences, Research tools, Therapeutics & prevention
Porous Membranes from Polyelectrolyte Coacervates
This invention demonstrates the use of polyelectrolyte complexes (PSS/PDADMAC) by leveraging the “saloplastic” properties as well as post-process annealing to fabricate sustainable, high-performance filtration membrane. This approach replaces traditional toxic organic solvents with water and salt, which does not only reduce environmental and health hazards but also simplifies the manufacturing process and cuts down on waste management costs.

Published: 11/18/2025   |   Inventor(s): Jessica Schiffman, Shao-Hsiang Hung
Category(s): Environmental, Engineering, Material science, Physical Science, Food technology & plant science, Healthcare
Flow Sensor Based on Coulometric Interrogation of a Graphene Microelectrode
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Published: 11/13/2025   |   Inventor(s): Jinglei Ping, Xiaoyu Zhang
Category(s): Devices & sensors, Engineering, Healthcare, Life Sciences, Research tools, Electronics
Localization of Payload Delivery Systems to Tumor Sites via Beacon Cell Targeting
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Published: 3/1/2024   |   Inventor(s): Neil Forbes, Nele Van Dessel, John Klier, Shane Taylor, Vishnu Raman
Category(s): Biotechnology, Healthcare, Life Sciences, Therapeutics & prevention
Noncationic Nucleic Acid-Polymer Complexes for Nucleic Acid Delivery
This invention provides a new strategy for nucleic acid delivery by using novel cross-linkable and surface-charge modifiable synthetic polymers. The use of the novel polymer system allows for robust nuclecid-polymer complexation, easy removal of cationic moieties of the polymer and self-crosslinking of the polymer in a single step, and stimuli-responsive release of the nucleic acid molecules in the cell.
Published: 11/29/2024   |   Inventor(s): Sankaran Thayumanavan
Category(s): Biotechnology, Healthcare, Nanotechnology, Life Sciences, Therapeutics & prevention
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