Economical Surface Treatment for Harvesting Epithelial Cells from Biological Fluids
Maria M. Santore, Ph.D.
• Engineered surfaces for selectively harvesting epithelial cells from biological fluids
• Surface treated microfluidic devices or glass beads for cancer diagnostics
• Engineered surfaces for cell-sorting applicationsfunction
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PERFORMANCE FACTORS
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Antibody- or Selectin-coated Microfluidic Channels
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Antibody- or Selectin-coated Functionalized Magnetic Beads
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DNA Aptamers
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THIS INVENTION
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Does not require expensive and unstable biomolecular materials for cell capture
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Distinguishing cells having different levels of the same surface adhesion marker
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Epithelial cell capture in complex biological fluids
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Unknown
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Tunable cell-type selectivity without the need of different targeting agents
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This invention provides economical, bio-interactive surfaces and surface treatment methods for selective capture of targeted epithelial cells or other cell types from cell mixtures or complex biological fluids. Preparation or fabrication of the engineered surfaces provided by this technology does not require the use of expensive and unstable biomolecular materials, and the resulting surfaces can distinguish different cell types or cells that express different levels of the same surface adhesion marker. Such engineered surfaces can be used as economical tools for assessment of cancer risk, cancer diagnosis, and tracking of the effectiveness of cancer treatments, among other potential applications.
Dr. Maria M. Santore is Professor of Polymer Science and Chemical Engineering at the University of Massachusetts Amherst. Her research group creates new materials for biomedical applications.
Available for Licensing and/or Sponsored Research
UMA 14-045
Patent Issued
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