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A Novel Treatment Facilitates Blastocyst Hatching
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Cell-Membrane-Coated Polymeric Nanoparticles for Selective Intracellular Delivery of Therapeutics
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Demineralized Bone Paper and Applications Thereof
This invention provides structurally well-defined, three-dimensional bone tissue grafts produced from stacked demineralized bone paper (DBP), methods for treating a subject using such bone tissue grafts, methods for making DBP, and in vitro assay systems and methods for assaying the effect of an agent on bone development or health.
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An Ex Vivo Method of Generating Super Regulatory T Cells as a Cell-based Therapy for the Prevention of Graft-vs-Host Disease
Regulatory T cells maintain immunological tolerance and dampen inflammatory responses. Administering regulatory T cells can prevent the immune-mediated tissue destruction of graft-versus-host disease, which frequently accompanies hematopoietic stem cell transfer. This technology provides a simple and effective method to generate and expand a unique population of stable and highly suppressive regulatory T cells, which can be used as a cell-based therapy for the prevention of graft-versus-host disease.
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Artificial Reproduction Technique
This invention provides a method to improve the functionality and/or fertility of sperm by subjecting the isolated sperm to a starvation protocol and/or ionophore. Said sperm can be used to increase artificial insemination by reducing the number of sperm needed as well as improving conception rates.
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Magnetohydrodynamic clearing and antibody staining
This invention provides devices and methods for the interrogation of molecular structure and function of virtually any biological tissue by allowing histological analyses of large biological tissues with numerous biomarkers (antibodies, RNAs, chemical labels). In addition, this technique maintains the integrity of large tissue samples making it possible to perform multiple rounds of histological staining to resolve 3-D organization of biological structures at the macroscopic and microscope scale.
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Let-7 promotes superior anti-tumor activity of CD8 T cells and memory formation
This invention demonstrates that let-7 miRNA regulates T cell responses and offers a strategy in developing next-generation immunotherapies by preserving the multipotency of effector cells rather than enhancing the efficacy of differentiation.
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Localization of Payload Delivery Systems to Tumor Sites via Beacon Cell Targeting
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Noncationic Nucleic Acid-Polymer Complexes for Nucleic Acid Delivery
This invention provides a new strategy for nucleic acid delivery by using novel cross-linkable and surface-charge modifiable synthetic polymers. The use of the novel polymer system allows for robust nuclecid-polymer complexation, easy removal of cationic moieties of the polymer and self-crosslinking of the polymer in a single step, and stimuli-responsive release of the nucleic acid molecules in the cell.
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Nanopore Tweezer System for Protein Kinase Allosteric Drug Screening
Protein kinases are enzymes that catalyze the phosphorylation of substrate proteins, regulating a wide range of cellular pathways. Aberrant kinase activities are implicated in various human diseases, making the kinases essential drug targets. This invention provides a nanopore-tweezer-based compound screening platform for the identification of allosteric drugs that can bind to allosteric sites on protein kinases and overcome drug resistance.
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