The University of Massachusetts Amherst

Search Results - Biotechnology

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Noncationic Nucleic Acid-Polymer Complexes for Nucleic Acid Delivery
Published: 10/26/2023   |   Inventor(s): Sankaran Thayumanavan
Category(s): Biotechnology, Healthcare, Nanotechnology, Life Sciences, Therapeutics & prevention
Nanopore Tweezer System for Protein Kinase Allosteric Drug Screening
Protein kinases are enzymes that catalyze the phosphorylation of substrate proteins, regulating a wide range of cellular pathways. Aberrant kinase activities are implicated in various human diseases, making the kinases essential drug targets. This invention provides a nanopore-tweezer-based compound screening platform for the identification of allosteric drugs that can bind to allosteric sites on protein kinases and overcome drug resistance.
Published: 8/3/2023   |   Inventor(s): Min Chen, Fanjun Li
Category(s): Biotechnology, Life Sciences, Research tools
Cell-Membrane-Coated Polymeric Nanoparticles for Selective Intracellular Delivery of Therapeutics
Published: 8/10/2023   |   Inventor(s): Sankaran Thayumanavan
Category(s): Healthcare, Life Sciences, Biotechnology, Nanotechnology, Therapeutics & prevention, Research tools
Demineralized Bone Paper and Applications Thereof
This invention provides structurally well-defined, three-dimensional bone tissue grafts produced from stacked demineralized bone paper (DBP), methods for treating a subject using such bone tissue grafts, methods for making DBP, and in vitro assay systems and methods for assaying the effect of an agent on bone development or health.
Published: 8/10/2023   |   Inventor(s): Jungwoo Lee, Jae-Hyuck Shim, Ryan Carpenter, Yongkuk Park, Jun-Goo Kwak
Category(s): Biotechnology, Devices, Healthcare, Life Sciences, Research tools, Therapeutics & prevention
Economical Surface Treatment for Harvesting Epithelial Cells from Biological Fluids
This invention provides economical, bio-interactive surfaces and surface treatment methods for selective capture of targeted epithelial cells or other cell types from cell mixtures or complex biological fluids. Preparation or fabrication of the engineered surfaces provided by this technology does not require the use of expensive and unstable biomolecular materials, and the resulting surfaces can distinguish different cell types or cells that express different levels of the same surface adhesion marker. Such engineered surfaces can be used as economical tools for assessment of cancer risk, cancer diagnosis, and tracking of the effectiveness of cancer treatments, among other potential applications.
Published: 8/10/2023   |   Inventor(s): Maria Santore, Kathleen Arcaro, Surachate Kalasin
Category(s): Biotechnology, Nanotechnology, Diagnostic technology, Devices & sensors, Life Sciences, Healthcare, Research tools
This invention provides economical, renewable surfaces and related methods for selective capture of bacteria in a fluid medium and for killing and/or release of the captured bacteria. The fabrication of these surfaces or surface-treated substrate materials does not require the use of expensive biomolecules and toxic chemicals. The surfaces capture and kill bacteria on contact without leaching any toxic antimicrobial agents. The surfaces can rapidly release captured or killed bacteria via mechanical means, and thus are easily renewable for subsequent round of bacterial capture, killing and release, which makes them ideal for use in on-line bacterial sensor systems. In addition, the surfaces can be engineered to selectively capture bacteria from complex fluid media or selectively capture one bacterial strain over another.
Published: 8/10/2023   |   Inventor(s): Maria Santore, Bing Fang
Category(s): Material science, Biotechnology, Devices & sensors
Cavitation Rheology for Measuring Local Mechanical Properties in Biologically Relevant Soft Materials
Measuring the mechanical properties of a complex biological tissue is crucial to developing knowledge about its physiology. Determining these physical properties in vivo is essential to innovation in tissue engineering, as well as to investigating the effects of aging and disease. Due to the heterogeneous structure of complex tissues, localized testing is necessary since probing surface properties only provides an incomplete picture of a tissue’s mechanical properties. Cavitation Rheology Technique (CRT), a novel methodology that originated in Dr. Alfred J. Crosby’s lab, succeeds where traditional techniques fall short. CRT involves measuring the pressure to induce cavitation at the tip of a needle within a soft material. This pressure is quantitatively related to the local modulus of the material. This allows for localized testing of non-transparent materials and tissues. Furthermore, CRT adopts a simple device and system design and requires only minimal amounts of sample material and testing time. This technique has been successfully demonstrated in a broad range of synthetic hydrogels and natural tissues, and can be applied in vivo.
Published: 8/3/2023   |   Inventor(s): Alfred Crosby, Jessica Zimberlin Eastman (pat agent)
Category(s): Biotechnology, Healthcare, Devices & sensors, Devices, Diagnostic technology, Material science
Geobacter Sulfurreducens Conductive Pili as Biological Nanowires and Uses Thereof

The present invention reports the conductive properties of Geobacter sulfurreducens pili (geopili) and their use in nanotechnology applications. More specifically the present invention provides methods for culturing cells of G. sulfurreducens to produce conductive pili, as well as methods for their isolation and for their modification in order to produce biological nanowires or biological/inorganic hybrid devices with different functionalities.  The invention provides applications for cells expressing native or modified pili as well as for the isolated native or modified pili.

Published: 12/9/2022   |   Inventor(s): Derek Lovley, Gemma Reguera, Kevin McCarthy, Mark Thomas Tuominen
Category(s): Life Sciences, Environmental, Nanotechnology, Biotechnology
Polymeric Nanogles for the Encapsulation, Delivery and pH-Triggered Release of Proteins
Published: 8/10/2023   |   Inventor(s): Sankaran Thayumanavan, Mijanur Molla, Scott Garman
Category(s): Biotechnology, Diagnostic technology, Healthcare, Life Sciences, Nanotechnology, Research tools
Polymeric Nanoparticle-Based Antibiofilm Therapy
This invention provides a novel therapeutic platform to combat multidrug-resistant bacterial and biofilm infections using engineered polymeric nanoparticles. The polymeric nanoparticles can penetrate and eradicate pre-formed bacterial biofilms while maintaining high therapeutic indices. The nanoparticles are formed via self-assembly of engineered synthetic polymers in aqueous solutions, without the need to use any organic solvent or purification procedures.
Published: 8/10/2023   |   Inventor(s): Vincent Rotello, Ryan Landis, Akash Gupta
Category(s): Healthcare, Life Sciences, Biotechnology, Therapeutics & prevention
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