The University of Massachusetts Amherst

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Economical Surface Treatment for Harvesting Epithelial Cells from Biological Fluids
This invention provides economical, bio-interactive surfaces and surface treatment methods for selective capture of targeted epithelial cells or other cell types from cell mixtures or complex biological fluids. Preparation or fabrication of the engineered surfaces provided by this technology does not require the use of expensive and unstable biomolecular materials, and the resulting surfaces can distinguish different cell types or cells that express different levels of the same surface adhesion marker. Such engineered surfaces can be used as economical tools for assessment of cancer risk, cancer diagnosis, and tracking of the effectiveness of cancer treatments, among other potential applications.
Published: 8/13/2020   |   Inventor(s): Maria Santore, Kathleen Arcaro, Surachate Kalasin
Category(s): Biotechnology, Nanotechnology, Diagnostic technology, Devices & sensors, Life Sciences, Healthcare, Research tools
RENEWABLE SURFACES FOR CAPTURE, KILLING AND RELEASE OF BACTERIA
This invention provides economical, renewable surfaces and related methods for selective capture of bacteria in a fluid medium and for killing and/or release of the captured bacteria. The fabrication of these surfaces or surface-treated substrate materials does not require the use of expensive biomolecules and toxic chemicals. The surfaces capture and kill bacteria on contact without leaching any toxic antimicrobial agents. The surfaces can rapidly release captured or killed bacteria via mechanical means, and thus are easily renewable for subsequent round of bacterial capture, killing and release, which makes them ideal for use in on-line bacterial sensor systems. In addition, the surfaces can be engineered to selectively capture bacteria from complex fluid media or selectively capture one bacterial strain over another.
Published: 8/13/2020   |   Inventor(s): Maria Santore, Bing Fang
Category(s): Material science, Biotechnology, Devices & sensors
Cavitation Rheology for Measuring Local Mechanical Properties in Biologically Relevant Soft Materials
Measuring the mechanical properties of a complex biological tissue is crucial to developing knowledge about its physiology. Determining these physical properties in vivo is essential to innovation in tissue engineering, as well as to investigating the effects of aging and disease. Due to the heterogeneous structure of complex tissues, localized testing is necessary since probing surface properties only provides an incomplete picture of a tissue’s mechanical properties. Cavitation Rheology Technique (CRT), a novel methodology that originated in Dr. Alfred J. Crosby’s lab, succeeds where traditional techniques fall short. CRT involves measuring the pressure to induce cavitation at the tip of a needle within a soft material. This pressure is quantitatively related to the local modulus of the material. This allows for localized testing of non-transparent materials and tissues. Furthermore, CRT adopts a simple device and system design and requires only minimal amounts of sample material and testing time. This technique has been successfully demonstrated in a broad range of synthetic hydrogels and natural tissues, and can be applied in vivo.
Published: 8/13/2020   |   Inventor(s): Alfred Crosby, Jessica Zimberlin Eastman (pat agent)
Category(s): Biotechnology, Healthcare, Devices & sensors, Devices, Diagnostic technology, Material science
Amphiphilic Polymer Capsules and Related Methods of Interfacial Assembly
A chemical crosslinking process is used to prepare capsules from PEGylated polyolefins using either oil-in-water (i.e., oil inside the capsule in a water-based system), or water-in-oil system. The covalent network structure of these capsules make them more robust than many other systems under investigation in controlled-release.The unique nature of the crosslinking chemistry is such that the crosslinks can be made either hydrolytically stable or unstable. Those with hydrolytically stable crosslinks have longer carrier lifetimes, while those with hydrolytically unstable crosslinks will degrade over a time period that can be controlled by crosslink density and the type of crosslinker used.
Published: 8/13/2020   |   Inventor(s): Todd Emrick, Kurt Breitenkamp
Category(s): Material science, Therapeutics & prevention, Biotechnology
Efficient Intracellular Protein Delivery and Traceless Release Using Mesoporous Silica Carriers Complexed with Reversibly Modified Protein
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Published: 12/24/2019   |   Inventor(s): Sankaran Thayumanavan, Bin Liu
Category(s): Biotechnology, Healthcare, Life Sciences, Research tools, Therapeutics & prevention
Novel Protein-Polymer Nanoassemblies for the Intracellular Delivery and Stimuli-responsive Traceless Release of Proteins
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Published: 12/24/2019   |   Inventor(s): Sankaran Thayumanavan, Bin Liu
Category(s): Biotechnology, Healthcare, Life Sciences, Nanotechnology, Research tools
Novel Chemical Reagents for Antibody-Drug Conjugation, Protein Delivery, and Traceless Release
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Published: 12/23/2019   |   Inventor(s): Sankaran Thayumanavan, Jiaming Zhuang
Category(s): Biotechnology, Life Sciences, Research tools
A Novel Non-cationic Lipid-polymer-based Nanossembly for the Complexation and Intracellular Delivery of Nucleic Acids
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Published: 12/20/2019   |   Inventor(s): Sankaran Thayumanavan, Kingshuk Dutta
Category(s): Biotechnology, Healthcare, Life Sciences, Nanotechnology, Therapeutics & prevention
Novel Polymeric Nanogels for Controlled Intracellular Protein Delivery and Traceless Release
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Published: 9/18/2019   |   Inventor(s): Sankaran Thayumanavan, Jiaming Zhuang
Category(s): Life Sciences, Biotechnology, Healthcare, Research tools, Therapeutics & prevention, Nanotechnology, Diagnostic technology
Novel Enzymatic Methods for Generating High-Yield, Ultrapure and Nonimmunogenic RNA
RNA is increasingly used as both a research and therapeutic tool to control gene expression. Currently, there are two established routes to generate synthetic RNA: chemically or enzymatically. While the chemical route is limited to RNAs shorter than about 30 nucleotide residues in length, the enzymatic route is routinely used to generate large quantities of short and long RNA in vitro using T7 RNA polymerase or one of its closely related family members. The enzymatic method, however, often generates undesired longer RNA products that could invoke unwanted immune responses in vivo. This invention provides novel enzymatic methods for generating high yields, ultrapure and non-immunogenic RNA.
Published: 9/16/2019   |   Inventor(s): Craig Martin, Elvan Cavac, Kithmie MalagodaPathiranage
Category(s): Research tools, Biotechnology, Healthcare, Life Sciences, Therapeutics & prevention
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