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Novel Polymeric Nanogels for Controlled Intracellular Protein Delivery and Traceless Release
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Published: 9/13/2019   |   Inventor(s): Sankaran Thayumanavan, Jiaming Zhuang
Category(s): Life Sciences, Biotechnology, Healthcare, Research tools, Therapeutics & prevention, Nanotechnology, Diagnostic technology
Economical Surface Treatment for Harvesting Epithelial Cells from Biological Fluids
This invention provides economical, bio-interactive surfaces and surface treatment methods for selective capture of targeted epithelial cells or other cell types from cell mixtures or complex biological fluids. Preparation or fabrication of the engineered surfaces provided by this technology does not require the use of expensive and unstable biomolecular materials, and the resulting surfaces can distinguish different cell types or cells that express different levels of the same surface adhesion marker. Such engineered surfaces can be used as economical tools for assessment of cancer risk, cancer diagnosis, and tracking of the effectiveness of cancer treatments, among other potential applications.
Published: 9/13/2019   |   Inventor(s): Maria Santore, Kathleen Arcaro, Surachate Kalasin
Category(s): Biotechnology, Nanotechnology, Diagnostic technology, Devices & sensors, Life Sciences, Healthcare, Research tools
RENEWABLE SURFACES FOR CAPTURE, KILLING AND RELEASE OF BACTERIA
This invention provides economical, renewable surfaces and related methods for selective capture of bacteria in a fluid medium and for killing and/or release of the captured bacteria. The fabrication of these surfaces or surface-treated substrate materials does not require the use of expensive biomolecules and toxic chemicals. The surfaces capture and kill bacteria on contact without leaching any toxic antimicrobial agents. The surfaces can rapidly release captured or killed bacteria via mechanical means, and thus are easily renewable for subsequent round of bacterial capture, killing and release, which makes them ideal for use in on-line bacterial sensor systems. In addition, the surfaces can be engineered to selectively capture bacteria from complex fluid media or selectively capture one bacterial strain over another.
Published: 9/13/2019   |   Inventor(s): Maria Santore, Bing Fang
Category(s): Material science, Biotechnology, Devices & sensors
Cavitation Rheology for Measuring Local Mechanical Properties in Biologically Relevant Soft Materials
Measuring the mechanical properties of a complex biological tissue is crucial to developing knowledge about its physiology. Determining these physical properties in vivo is essential to innovation in tissue engineering, as well as to investigating the effects of aging and disease. Due to the heterogeneous structure of complex tissues, localized testing is necessary since probing surface properties only provides an incomplete picture of a tissue’s mechanical properties. Cavitation Rheology Technique (CRT), a novel methodology that originated in Dr. Alfred J. Crosby’s lab, succeeds where traditional techniques fall short. CRT involves measuring the pressure to induce cavitation at the tip of a needle within a soft material. This pressure is quantitatively related to the local modulus of the material. This allows for localized testing of non-transparent materials and tissues. Furthermore, CRT adopts a simple device and system design and requires only minimal amounts of sample material and testing time. This technique has been successfully demonstrated in a broad range of synthetic hydrogels and natural tissues, and can be applied in vivo.
Published: 9/13/2019   |   Inventor(s): Alfred Crosby, Jessica Zimberlin Eastman (pat agent)
Category(s): Biotechnology, Healthcare, Devices & sensors, Devices, Diagnostic technology, Material science
Amphiphilic Polymer Capsules and Related Methods of Interfacial Assembly
A chemical crosslinking process is used to prepare capsules from PEGylated polyolefins using either oil-in-water (i.e., oil inside the capsule in a water-based system), or water-in-oil system. The covalent network structure of these capsules make them more robust than many other systems under investigation in controlled-release.The unique nature of the crosslinking chemistry is such that the crosslinks can be made either hydrolytically stable or unstable. Those with hydrolytically stable crosslinks have longer carrier lifetimes, while those with hydrolytically unstable crosslinks will degrade over a time period that can be controlled by crosslink density and the type of crosslinker used.
Published: 9/13/2019   |   Inventor(s): Todd Emrick, Kurt Breitenkamp
Category(s): Material science, Therapeutics & prevention, Biotechnology
Hyaluronic Acid Based Nanogel or Microgel Compositions for Targeted Delivery of Small Molecule Therapeutics
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Published: 9/13/2019   |   Inventor(s): Sankaran Thayumanavan, Lisa Minter
Category(s): Biotechnology, Diagnostic technology, Healthcare, Life Sciences, Nanotechnology, Research tools, Therapeutics & prevention
A Simple Method of Making Biocompatible Protein Films as Antimicrobial Coatings
This invention provides a simple method for making protein films or coatings for antifouling, antimicrobial, and tissue engineering applications. The films are water-stable, biocompatible and resistant to protein and bacterial fouling. The films can be fabricated on substrates with simple or complex geometries. The biodegradability of the films can be tuned to enable controlled release of functional or therapeutic agents.
Published: 7/26/2018   |   Inventor(s): Vincent Rotello, Li-Sheng Wang, Sanjana Gopalakrishnan
Category(s): Healthcare, Life Sciences, Engineering, Biotechnology
Aerobic Microbial Fuel Cell
Microbial fuel cells (MFCs) convert organic matter into electrical energy, and find applications in electricity generation and sensor powering for soil, salt and fresh water, and commercial waste environments. Typically, the anode chamber of the MFC must be kept under anaerobic conditions because of anoxic requirements for the bacteria. This both increases engineering costs and impedes proton transfer from the anode to the cathode.

 

Dr. Kelly Nevin Lovley and Dr. Derek Lovley patented an aerobic MFC anode electrode, allowing for the aerobic operation of an MFC. In their single-chambered design, an internal reservoir of fuel-bearing liquid is created at the anode. The anode is porous, allowing the fuel (e.g. acetate) to diffuse out and form a thick layer. At the outer layer of biofilm, oxygen will be reduced to water and the acetate fuel will be oxidized to CO2. This outer layer protects the inner layer from rapid oxidation, allowing the bacteria to generate current for weeks at a time.

Published: 12/14/2017   |   Inventor(s): Kelly Nevin Lovley, Derek Lovley
Category(s): Biotechnology, Life Sciences, Environmental
Polymeric Nanocapsules for the Treatment of Biofilms
Bacterial biofilms are widely associated with persistent infections. The amphiphilic construct of biofilms provides protection for bacterial cells by reducing absorption of conventional antimicrobials. This invention provides new antimicrobial nanocapsules that can effectively inhibit and eradiate pathogenic biofilms. The nanocapsules contain an antimicrobial essential oil and can efficiently deliver the essential oil to the cells of pathogenic bacteria in the biofilm, resulting in effective killing of the bacteria.
Published: 9/14/2015   |   Inventor(s): Vincent Rotello, Ryan Landis, Akash Gupta, Yiwei Lee
Category(s): Biotechnology, Healthcare, Life Sciences, Nanotechnology, Therapeutics & prevention
Polymeric Nanocapsules for Efficient Intracellular Delivery of Theraputic Proteins
Designing protein therapeutics is becoming one of the fastest growing strategies to treat a variety of diseases including cancer and diabetes. Clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9, a bacterially constructed protein-nucleic acid complex has shown great potential to reverse various genetic disorders. The delivery of this complex into the cell and finally the nucleus is challenging, however, due to the large size of the Cas9 protein. This invention provides a general and efficient protein delivery platform that enables the intracellular delivery of therapeutic proteins. The delivery system involves the use of novel synthetic polymers capable of forming nanocapsules spontaneously under controlled conditions.
Published: 6/22/2015   |   Inventor(s): Vincent Rotello, Ryan Landis, Moumita Ray
Category(s): Biotechnology, Life Sciences, Research tools, Healthcare, Therapeutics & prevention
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