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Economical Surface Treatment for Harvesting Epithelial Cells from Biological Fluids
This invention provides economical, bio-interactive surfaces and surface treatment methods for selective capture of targeted epithelial cells or other cell types from cell mixtures or complex biological fluids. Preparation or fabrication of the engineered surfaces provided by this technology does not require the use of expensive and unstable biomolecular materials, and the resulting surfaces can distinguish different cell types or cells that express different levels of the same surface adhesion marker. Such engineered surfaces can be used as economical tools for assessment of cancer risk, cancer diagnosis, and tracking of the effectiveness of cancer treatments, among other potential applications.
Published: 6/11/2021   |   Inventor(s): Maria Santore, Kathleen Arcaro, Surachate Kalasin
Category(s): Biotechnology, Nanotechnology, Diagnostic technology, Devices & sensors, Life Sciences, Healthcare, Research tools
Polymeric Nanogles for the Encapsulation, Delivery and pH-Triggered Release of Proteins
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Published: 6/11/2021   |   Inventor(s): Sankaran Thayumanavan, Mijanur Molla, Scott Garman
Category(s): Biotechnology, Diagnostic technology, Healthcare, Life Sciences, Nanotechnology, Research tools
Nature-Inspired Nanosponges as Antibacterial and Antifungal Agents
This invention provides nature-inspired nanosponges capable of penetrating and eradicating bacterial biofilms and eliminating drug-resistant fungi. The nanosponges are nanoparticles composed of antimicrobial essential oil and crosslinked gelatin, and can be used in a wide-variety of antibacterial and antifungal applications.
Published: 5/17/2021   |   Inventor(s): Vincent Rotello, Ryan Landis
Category(s): Food technology & plant science, Life Sciences, Environmental, Healthcare, Nanotechnology, Therapeutics & prevention
Polymeric Nanoparticle-Based Antibiofilm Therapy
This invention provides a novel therapeutic platform to combat multidrug-resistant bacterial and biofilm infections using engineered polymeric nanoparticles. The polymeric nanoparticles can penetrate and eradicate pre-formed bacterial biofilms while maintaining high therapeutic indices. The nanoparticles are formed via self-assembly of engineered synthetic polymers in aqueous solutions, without the need to use any organic solvent or purification procedures.
Published: 5/14/2021   |   Inventor(s): Vincent Rotello, Ryan Landis, Akash Gupta
Category(s): Healthcare, Life Sciences, Biotechnology, Therapeutics & prevention
Noncationic Nucleic Acid-Polymer Complexes for Nucleic Acid Delivery
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Published: 5/11/2021   |   Inventor(s): Sankaran Thayumanavan
Category(s): Biotechnology, Healthcare, Nanotechnology, Life Sciences, Therapeutics & prevention
Miniaturized, Cost-Effective Biosensing Devices for Point-of-Care and Therapeutic Screening Applications
This invention provides miniaturized and portable biosensing devices that employ novel spectrally-filtered photodiode pairs and on-chip ratiometric sensing. The biosensing devices allow for rapid, high-precision detection of biomolecules of interest, and can be used for point-of-care and therapeutic screening applications.
Published: 5/7/2021   |   Inventor(s): Guangyu Xu
Category(s): Biotechnology, Devices, Devices & sensors, Diagnostic technology, Healthcare, Life Sciences, Engineering, Research tools
An Ex Vivo Method of Generating Super Regulatory T Cells as a Cell-based Therapy for the Prevention of Graft-vs-Host Disease
Regulatory T cells maintain immunological tolerance and dampen inflammatory responses. Administering regulatory T cells can prevent the immune-mediated tissue destruction of graft-versus-host disease, which frequently accompanies hematopoietic stem cell transfer. This technology provides a simple and effective method to generate and expand a unique population of stable and highly suppressive regulatory T cells, which can be used as a cell-based therapy for the prevention of graft-versus-host disease.
Published: 1/28/2021   |   Inventor(s): Lisa Minter, Gregory Tew, Emrah Ozay
Category(s): Biotechnology, Healthcare, Life Sciences, Research tools, Therapeutics & prevention
Novel Small Molecule Inhibitors of Caspase-6
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Published: 7/2/2020   |   Inventor(s): Jeanne Hardy, Penchala Narasimharao Meka
Category(s): Therapeutics & prevention, Life Sciences, Healthcare
Novel Protein-Polymer Nanoassemblies for the Intracellular Delivery and Stimuli-responsive Traceless Release of Proteins
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Published: 12/24/2019   |   Inventor(s): Sankaran Thayumanavan, Bin Liu
Category(s): Biotechnology, Healthcare, Life Sciences, Nanotechnology, Research tools
Novel Chemical Reagents for Antibody-Drug Conjugation, Protein Delivery, and Traceless Release
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Published: 12/23/2019   |   Inventor(s): Sankaran Thayumanavan, Jiaming Zhuang
Category(s): Biotechnology, Life Sciences, Research tools
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