Search Results - life+sciences

Oils are susceptible to lipid oxidation that causes the formation of off flavors and potentially toxic compounds. Lipid oxidation is the limiting factor for the shelf life of oils and thus results in food waste. This invention provides a novel method to make natural, food-grade antioxidants that can be used as food additives to extend the shelf life of a wide variety of lipid-containing food products and oils used in food preparation, cooking and flavoring. The method involves enzymatic conversion of naturally derived lecithin into food-grade antioxidants.

This invention provides structurally well-defined, three-dimensional bone tissue grafts produced from stacked demineralized bone paper (DBP), methods for treating a subject using such bone tissue grafts, methods for making DBP, and in vitro assay systems and methods for assaying the effect of an agent on bone development or health.

Regulatory T cells maintain immunological tolerance and dampen inflammatory responses. Administering regulatory T cells can prevent the immune-mediated tissue destruction of graft-versus-host disease, which frequently accompanies hematopoietic stem cell transfer. This technology provides a simple and effective method to generate and expand a unique population of stable and highly suppressive regulatory T cells, which can be used as a cell-based therapy for the prevention of graft-versus-host disease.

This invention demonstrates the functionalization of electronically conductive protein nanowires (e-PNs) with one or more peptides (e.g. “His-tag” , “HA-tag”) while maintaining, or possibly increasing, their conductivity. The ability to decorate e-PNs greatly expand the potential application in electronic devices and for the fabrication of electrically conductive composite materials.

This invention provides a method to improve the functionality and/or fertility of sperm by subjecting the isolated sperm to a starvation protocol and/or ionophore. Said sperm can be used to increase artificial insemination by reducing the number of sperm needed as well as improving conception rates.

This invention provides devices and methods for the interrogation of molecular structure and function of virtually any biological tissue  by allowing histological analyses of large biological tissues with numerous biomarkers (antibodies, RNAs, chemical labels). In addition, this technique maintains the integrity of large tissue samples making it possible to perform multiple rounds of histological staining to resolve 3-D organization of biological structures at the macroscopic and microscope scale.

This invention demonstrates that let-7 miRNA  regulates T cell responses and offers a strategy in developing next-generation immunotherapies by preserving the multipotency of effector cells rather than enhancing the efficacy of differentiation.

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This invention provides a new strategy for nucleic acid delivery by using novel cross-linkable and surface-charge modifiable synthetic polymers. The use of the novel polymer system allows for robust nuclecid-polymer complexation, easy removal of cationic moieties of the polymer and self-crosslinking of the polymer in a single step, and stimuli-responsive release of the nucleic acid molecules in the cell.