The University of Massachusetts Amherst

Search Results - john+klier

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Reactive Particles for Cold Spray Coatings
This invention demonstrates solid or semi-solid microparticles that undergo crosslinking and polymerization upon contacting a substrate to form a coating. The microparticles are maintained in an un-reacted state until delivered using cold spray processes where they are propelled using a gas stream at a pre-determined temperature and velocity. The process does not require volatile organic solvents or aqueous vehicles, nor plural component spray or two component formulations with limited shelf life but still deliver uniform coating.
Published: 11/18/2024   |   Inventor(s): Jessica Schiffman, Victor Champagne, John Klier, Guozhen Yang, Mengfei Huang
Category(s): Chemicals, Engineering, Material science, Nanotechnology
Localization of Payload Delivery Systems to Tumor Sites via Beacon Cell Targeting
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Published: 3/1/2024   |   Inventor(s): Neil Forbes, Nele Van Dessel, John Klier, Shane Taylor, Vishnu Raman
Category(s): Biotechnology, Healthcare, Life Sciences, Therapeutics & prevention
Pressure Sensitive Adhesives
Pressure sensitive adhesives bond two materials when physical pressure is applied to marry the adhesive with the adherent. They are widely applied in self-adhesive tapes, labels and marking films, medical plasters and pads, dermal pharmaceutical dosage forms, medical drapes and biomedical electrodes. Curing current adhesives often involves UV irradiation or heat, capital and energy intensive steps which may produce to toxic byproducts.

 

The invention concerns novel compositions and crosslinking strategies that greatly simplify fabrication of pressure sensitive adhesives.  A soluble and flowable polymer containing latent crosslinking sites is applied to a substrate as a low-viscosity solution or melt.  After application, spontaneous crosslinking occurs at ambient conditions, eliminating the need for post-crosslinking equipment, capital and expense. It also eliminates formation of undesired or toxic residues; allows the formation of crosslinked adhesive layers on temperature-sensitive substrates; enables the use of opaque crosslinkable adhesive formulations; and facilitates the incorporation of adhesives into porous or complex substrates. These strategies may be generalized to broader classes of solvent borne and hot melt pressure adhesives.

 

Published: 1/17/2024   |   Inventor(s): Shelly Peyton, John Klier, Yen Tran, Todd Emrick
Category(s): Engineering, Healthcare, Material science