Nanopore Tweezer System for Protein Kinase Allosteric Drug Screening
• Nanopore-tweezer-based system for efficient kinase allosteric drug screening
• Label-free method
• Capable of identifying both allosteric inhibitors and activators
• Capable of distinguishing active-site inhibitors from allosteric inhibitors
• Prior knowledge of protein structure not required for allosteric binder identification
Protein kinases are enzymes that catalyze the phosphorylation of substrate proteins, regulating a wide range of cellular pathways. Aberrant kinase activities are implicated in various human diseases, making the kinases essential drug targets. This invention provides a nanopore-tweezer-based compound screening platform for the identification of allosteric drugs that can bind to allosteric sites on protein kinases and overcome drug resistance.
Dr. Min Chen is an Asociate Professor in the Department of Chemistry at the University of Massachusetts Amherst. Her research group focuses on developing engineered protein pores for biosensing applications.
Available for Licensing and/or Sponsored Research
UMA 23-008
F
Patent Pending
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