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Flow Sensor Based on Coulometric Interrogation of a Graphene Microelectrode
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Localization of Payload Delivery Systems to Tumor Sites via Beacon Cell Targeting
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Noncationic Nucleic Acid-Polymer Complexes for Nucleic Acid Delivery
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Nanopore Tweezer System for Protein Kinase Allosteric Drug Screening
Protein kinases are enzymes that catalyze the phosphorylation of substrate proteins, regulating a wide range of cellular pathways. Aberrant kinase activities are implicated in various human diseases, making the kinases essential drug targets. This invention provides a nanopore-tweezer-based compound screening platform for the identification of allosteric drugs that can bind to allosteric sites on protein kinases and overcome drug resistance.
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Cell-Membrane-Coated Polymeric Nanoparticles for Selective Intracellular Delivery of Therapeutics
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Nanopore-based Sensors for Antibody Screening Applications
This invention provides OmpG nanopore-based sensors for antibody screening applications. Each OmpG nanopore is engineered to contain a heterologous peptide sequence in one or more flexible loops of the nanopore, allowing for target-specific binding and detection.
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Novel Ferroptosis Inducing Compounds as Anti-cancer Agents
Ferroptosis is a well-defined cell death mechanism distinct from other regulated cell death phenotypes such as apoptosis, necrosis and autophagy. This invention provides novel ferroptosis inducer compounds that represent a new class of highly specific chemotherapeutic agents.
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Demineralized Bone Paper and Applications Thereof
This invention provides structurally well-defined, three-dimensional bone tissue grafts produced from stacked demineralized bone paper (DBP), methods for treating a subject using such bone tissue grafts, methods for making DBP, and in vitro assay systems and methods for assaying the effect of an agent on bone development or health.
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Economical Surface Treatment for Harvesting Epithelial Cells from Biological Fluids
This invention provides economical, bio-interactive surfaces and surface treatment methods for selective capture of targeted epithelial cells or other cell types from cell mixtures or complex biological fluids. Preparation or fabrication of the engineered surfaces provided by this technology does not require the use of expensive and unstable biomolecular materials, and the resulting surfaces can distinguish different cell types or cells that express different levels of the same surface adhesion marker. Such engineered surfaces can be used as economical tools for assessment of cancer risk, cancer diagnosis, and tracking of the effectiveness of cancer treatments, among other potential applications.
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Geobacter Sulfurreducens Conductive Pili as Biological Nanowires and Uses Thereof
The present invention reports the conductive properties of Geobacter sulfurreducens pili (geopili) and their use in nanotechnology applications. More specifically the present invention provides methods for culturing cells of G. sulfurreducens to produce conductive pili, as well as methods for their isolation and for their modification in order to produce biological nanowires or biological/inorganic hybrid devices with different functionalities. The invention provides applications for cells expressing native or modified pili as well as for the isolated native or modified pili. |
