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A Simple Method of Making Biocompatible Protein Films as Antimicrobial Coatings
This invention provides a simple method for making protein films or coatings for antifouling, antimicrobial, and tissue engineering applications. The films are water-stable, biocompatible and resistant to protein and bacterial fouling. The films can be fabricated on substrates with simple or complex geometries. The biodegradability of the films can be tuned to enable controlled release of functional or therapeutic agents.
Published: 7/26/2018   |   Inventor(s): Vincent Rotello, Li-Sheng Wang, Sanjana Gopalakrishnan
Category(s): Healthcare, Life Sciences, Engineering, Biotechnology
Water-Soluble Temozolomide Derivatives and Polymer-Temozolomide Conjugates for Enhanced Glioblastoma Treatment
This invention provides novel compositions of water-soluble small molecule temozolomide derivatives and water-soluble polymer-temozolomide conjugates for enhanced treatment of glioblastoma multiforme.
Published: 5/9/2018   |   Inventor(s): Todd Emrick, Matthew Skinner
Category(s): Therapeutics & prevention, Life Sciences, Healthcare
Genetic Engineering of a Microbial Chassis for Electrosynthesis and Electrofermentation
With rapidly increasing proliferation and declining costs of renewable energy generation, methods of storing excess electricity become increasingly important. One such method was previously patented by Dr. Derek Lovley and Dr. Kelly Nevin. In their patented method, microorganisms use electricity to convert water and carbon dioxide into multi-carbon chemicals and fuels, akin to the reverse operation of a microbial fuel cell. This invention builds upon the inventors’ patent. Here, they created a genetically-modified strain of Geobacter sulfurreducens, whose electrical current consumption rate is more than 10x higher than the wild-type strain, greatly enhancing the conversion process. This new strain also provides a platform for producing a wide variety of high-value carbonaceous products previously not possible through this method.
Published: 5/3/2018   |   Inventor(s): Derek Lovley, Toshiyuki Ueki, Kelly Nevin Lovley
Category(s): Chemicals, Clean Energy, Life Sciences
Aerobic Microbial Fuel Cell
Microbial fuel cells (MFCs) convert organic matter into electrical energy, and find applications in electricity generation and sensor powering for soil, salt and fresh water, and commercial waste environments. Typically, the anode chamber of the MFC must be kept under anaerobic conditions because of anoxic requirements for the bacteria. This both increases engineering costs and impedes proton transfer from the anode to the cathode.

 

Dr. Kelly Nevin Lovley and Dr. Derek Lovley patented an aerobic MFC anode electrode, allowing for the aerobic operation of an MFC. In their single-chambered design, an internal reservoir of fuel-bearing liquid is created at the anode. The anode is porous, allowing the fuel (e.g. acetate) to diffuse out and form a thick layer. At the outer layer of biofilm, oxygen will be reduced to water and the acetate fuel will be oxidized to CO2. This outer layer protects the inner layer from rapid oxidation, allowing the bacteria to generate current for weeks at a time.

Published: 12/14/2017   |   Inventor(s): Kelly Nevin Lovley, Derek Lovley
Category(s): Biotechnology, Life Sciences, Environmental
Method of Non-Chromatographic Purification of Monoclonal Antibodies
The potent pharmacodynamics and numerous diagnostics of monoclonal antibodies (mAbs) have led to their extensive use as therapeutic treatments for various cancers and autoimmune disorders, and for diagnostic assays. However, rapid developments in the foundational cell biology and recombinant technology of mAbs have not been matched by progress in downstream purification, a major determinant of mAb cost. 

 

mAb purification, largely reliant on chromatography (e.g. Protein A chromatography), is the principal determinant of drug cost. The present invention generally relates to non-chromatographic purification of mAbs, and particularly, to a method of purification of monoclonal antibodies via selective coacervation with hyaluronic acid. The method separates mAb from unwanted proteins and nucleic acids secreted from mAb-producing hybridoma cells, forming a fluid coacervate from which the mAb is purified. This promising technique may be an effective alternative for Protein A chromatography.

Published: 8/10/2017   |   Inventor(s): Paul Dubin, Rachel Wollacott, Daniel Seeman, Alex Malanowski
Category(s): Biotechnology, Healthcare, Life Sciences, Therapeutics & prevention
Inhibiting Proteases to Accelerate Wound Repair
This invention relates to the use of a protein therapeutic to block the activated and over-expressed proteases that lead to chronic wounds and thinning of the dermis in aging.
Published: 9/8/2016   |   Inventor(s): Annette Wysocki, Margaret Riley
Category(s): Healthcare, Life Sciences, Therapeutics & prevention
Displaying Physical Activity and Exercise Information
It is well appreciated that physical activity is beneficial for health and that long periods of sitting can be detrimental. Individuals use wearable activity trackers to inform themselves of salient data necessary for completion of activity goals (e.g. 10,000 steps per day). However, to date, devices do not provide movement information in context of overall activity patterns, rather they focus on only one metric of behavior. Thus, a user may not fully appreciate how much time they engaged in sedentary behaviors vs. active behaviors during a day or how much overall effort they used.

 

To address this problem, Dr. Tudor-Locke and her team have devised a simple, dynamic goal driven triangle graphic that display movement and non-movement data in an integrated fashion that can be displayed on wearable devices. Specifically, the arms of the triangle represent step number, effort, and sedentary time. As this information changes throughout the day based on behavior, the triangle will shift in both shape and size. This simple representation will allow the user to visualize their physical activity and exercise in the context of overall activity behavior. The use of simple, intuitive figures that provide individuals with integrated metrics of movement behavior may encourage individuals to make small tweaks in daily behavioral patterns, namely increasing the amount and intensity of physical activity and decreasing sedentary behavior, which could lead to significant health benefits.

Published: 2/25/2016   |   Inventor(s): Catrine Tudor-Locke, Michael Busa
Category(s): Electronics, Healthcare, Life Sciences, Software & information technology
Nanoparticle-Stabilized Microcapsules for Effective Treatment of Bacterial Biofilms
Bacterial biofilms are widely associated with persistent infections. The amphiphilic construct of biofilms provides protection for bacterial cells by reducing absorption of conventional antimicrobials. This invention provides new nanoparticle-stabilized antimicrobial microcapsules that can effectively inhibit and eradicate pathogenic biofilms. The microcapsules contain antimicrobial essential oil materials and can efficiently deliver such materials to the cells of pathogenic bacteria in the biofilm, resulting in effective killing of the bacteria.
Published: 10/5/2015   |   Inventor(s): Vincent Rotello, Bradley Duncan, Xiaoning A/k/a Sharlene Li
Category(s): Healthcare, Life Sciences, Nanotechnology, Therapeutics & prevention
Polymeric Nanocapsules for the Treatment of Biofilms
Bacterial biofilms are widely associated with persistent infections. The amphiphilic construct of biofilms provides protection for bacterial cells by reducing absorption of conventional antimicrobials. This invention provides new antimicrobial nanocapsules that can effectively inhibit and eradiate pathogenic biofilms. The nanocapsules contain an antimicrobial essential oil and can efficiently deliver the essential oil to the cells of pathogenic bacteria in the biofilm, resulting in effective killing of the bacteria.
Published: 9/14/2015   |   Inventor(s): Vincent Rotello, Ryan Landis, Akash Gupta, Yiwei Lee
Category(s): Biotechnology, Healthcare, Life Sciences, Nanotechnology, Therapeutics & prevention
Polymeric Nanocapsules for Efficient Intracellular Delivery of Theraputic Proteins
Designing protein therapeutics is becoming one of the fastest growing strategies to treat a variety of diseases including cancer and diabetes. Clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9, a bacterially constructed protein-nucleic acid complex has shown great potential to reverse various genetic disorders. The delivery of this complex into the cell and finally the nucleus is challenging, however, due to the large size of the Cas9 protein. This invention provides a general and efficient protein delivery platform that enables the intracellular delivery of therapeutic proteins. The delivery system involves the use of novel synthetic polymers capable of forming nanocapsules spontaneously under controlled conditions.
Published: 6/22/2015   |   Inventor(s): Vincent Rotello, Ryan Landis, Moumita Ray
Category(s): Biotechnology, Life Sciences, Research tools, Healthcare, Therapeutics & prevention
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