Search Results - Life+Sciences

This invention provides a method to improve the functionality and/or fertility of sperm by subjecting the isolated sperm to a starvation protocol and/or ionophore. Said sperm can be used to increase artificial insemination by reducing the number of sperm needed as well as improving conception rates.

This invention provides devices and methods for the interrogation of molecular structure and function of virtually any biological tissue  by allowing histological analyses of large biological tissues with numerous biomarkers (antibodies, RNAs, chemical labels). In addition, this technique maintains the integrity of large tissue samples making it possible to perform multiple rounds of histological staining to resolve 3-D organization of biological structures at the macroscopic and microscope scale.

This invention demonstrates that let-7 miRNA  regulates T cell responses and offers a strategy in developing next-generation immunotherapies by preserving the multipotency of effector cells rather than enhancing the efficacy of differentiation.

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This invention provides a new strategy for nucleic acid delivery by using novel cross-linkable and surface-charge modifiable synthetic polymers. The use of the novel polymer system allows for robust nuclecid-polymer complexation, easy removal of cationic moieties of the polymer and self-crosslinking of the polymer in a single step, and stimuli-responsive release of the nucleic acid molecules in the cell.

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This invention provides OmpG nanopore-based sensors for antibody screening applications. Each OmpG nanopore is engineered to contain a heterologous peptide sequence in one or more flexible loops of the nanopore, allowing for target-specific binding and detection.

Ferroptosis is a well-defined cell death mechanism distinct from other regulated cell death phenotypes such as apoptosis, necrosis and autophagy. This invention provides novel ferroptosis inducer compounds that represent a new class of highly specific chemotherapeutic agents.