Magnetohydrodynamic clearing and antibody staining
Devices and methods for moving charged molecules into and out of tissue samples
- Significantly reduces the time required to clear tissue samples
- Significantly reduces the time required for histological procedures in large tissue samples
- Removes biomarkers from tissue samples
- Minimizes overall damage to the biological tissue samples
- Maximizes quality of biological tissue samples
- Allows deeper penetration/analysis of biological tissue
- Allows for multiple rounds of histological staining and de-staining in a single sample
- Low-cost of production and durable device
This invention provides devices and methods for the interrogation of molecular structure and function of virtually any biological tissue by allowing histological analyses of large biological tissues with numerous biomarkers (antibodies, RNAs, chemical labels). In addition, this technique maintains the integrity of large tissue samples making it possible to perform multiple rounds of histological staining to resolve 3-D organization of biological structures at the macroscopic and microscope scale.
Available for Licensing and/or Sponsored Research
UMA 17-049
F
Patent Issued US 11,863,041 B2
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