Search Results - sankaran+thayumanavan

This invention provides a new strategy for nucleic acid delivery by using novel cross-linkable and surface-charge modifiable synthetic polymers. The use of the novel polymer system allows for robust nuclecid-polymer complexation, easy removal of cationic moieties of the polymer and self-crosslinking of the polymer in a single step, and stimuli-responsive release of the nucleic acid molecules in the cell.

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Selective and enhanced detection of peptides from complex mixtures. A special class of polymers is used to selectively extract and concentrate peptides of interest from complex mixtures, while simultaneously enhancing their detection using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry.

This technology provides a new class of structurally robust smart organic nanoparticles that are formed from covalently linked organic molecules. These organic nanoparticles can be produced in one step from two readily synthesized organic starting materials in the presence of a surfactant. Unlike inorganic nanomaterials such as quantum dots and gold nanoparticles, the smart nanoparticles provided by this technology not only can be produced with excellent control over their size and conveniently functionalized surfaces, but also can act as hosts for hydrophobic guest molecules and can subsequently self-disassemble and release the guests in response to specific environmental stimuli.