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Noncationic Nucleic Acid-Polymer Complexes for Nucleic Acid Delivery
This invention provides a new strategy for nucleic acid delivery by using novel cross-linkable and surface-charge modifiable synthetic polymers. The use of the novel polymer system allows for robust nuclecid-polymer complexation, easy removal of cationic moieties of the polymer and self-crosslinking of the polymer in a single step, and stimuli-responsive release of the nucleic acid molecules in the cell.
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Cell-Membrane-Coated Polymeric Nanoparticles for Selective Intracellular Delivery of Therapeutics
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Polymeric Nanogles for the Encapsulation, Delivery and pH-Triggered Release of Proteins
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Novel Protein-Polymer Nanoassemblies for the Intracellular Delivery and Stimuli-responsive Traceless Release of Proteins
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Novel Chemical Reagents for Antibody-Drug Conjugation, Protein Delivery, and Traceless Release
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New Protein Labeling Reagents for Improved Protein Structural Analysis by Mass Spectrometry
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A Novel Non-cationic Lipid-polymer-based Nanossembly for the Complexation and Intracellular Delivery of Nucleic Acids
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Novel Polymeric Nanogels for Controlled Intracellular Protein Delivery and Traceless Release
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Hyaluronic Acid Based Nanogel or Microgel Compositions for Targeted Delivery of Small Molecule Therapeutics
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Enhanced Charge Transport Through Nanoconfinement
A team of accomplished researchers at the University of Massachusetts Amherst has discovered a novel pathway for enhancing anhydrous proton transport in polymeric materials. This pathway entails generating supramolecular nanoscale confinement in polymers containing anhydrous proton transport functionalities. By carefully designing the polymer structures, the proton transport moieties of the polymers can be confined and organized within the nanoscale domains of the polymers via self-assembly, resulting in enhanced proton transport capabilities. This enhancement improves the conductivity of the polymers by 2-3 orders of magnitude. The high conductivities observed for the polymers with nanoconfinements are correlated with their ability to form locally high concentrations of proton transport moieties. These polymers allow high conductivities at high temperatures, which can increase fuel cell efficiency, lower cost, simplify heat management, and provide better tolerance of the fuel cell catalysts against poisoning.
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