The University of Massachusetts Amherst

Search Results - sankaran+thayumanavan

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Polymeric Nanogles for the Encapsulation, Delivery and pH-Triggered Release of Proteins
Published: 6/11/2021   |   Inventor(s): Sankaran Thayumanavan, Mijanur Molla, Scott Garman
Category(s): Biotechnology, Diagnostic technology, Healthcare, Life Sciences, Nanotechnology, Research tools
Noncationic Nucleic Acid-Polymer Complexes for Nucleic Acid Delivery
Published: 5/11/2021   |   Inventor(s): Sankaran Thayumanavan
Category(s): Biotechnology, Healthcare, Nanotechnology, Life Sciences, Therapeutics & prevention
Novel Protein-Polymer Nanoassemblies for the Intracellular Delivery and Stimuli-responsive Traceless Release of Proteins
Published: 12/24/2019   |   Inventor(s): Sankaran Thayumanavan, Bin Liu
Category(s): Biotechnology, Healthcare, Life Sciences, Nanotechnology, Research tools
Novel Chemical Reagents for Antibody-Drug Conjugation, Protein Delivery, and Traceless Release
Published: 12/23/2019   |   Inventor(s): Sankaran Thayumanavan, Jiaming Zhuang
Category(s): Biotechnology, Life Sciences, Research tools
New Protein Labeling Reagents for Improved Protein Structural Analysis by Mass Spectrometry
Published: 12/23/2019   |   Inventor(s): Richard Vachet, Sankaran Thayumanavan, Bo Zhao, Jiaming Zhuang
Category(s): Chemicals, Life Sciences, Research tools
A Novel Non-cationic Lipid-polymer-based Nanossembly for the Complexation and Intracellular Delivery of Nucleic Acids
Published: 12/20/2019   |   Inventor(s): Sankaran Thayumanavan, Kingshuk Dutta
Category(s): Biotechnology, Healthcare, Life Sciences, Nanotechnology, Therapeutics & prevention
Novel Polymeric Nanogels for Controlled Intracellular Protein Delivery and Traceless Release
Published: 9/18/2019   |   Inventor(s): Sankaran Thayumanavan, Jiaming Zhuang
Category(s): Life Sciences, Biotechnology, Healthcare, Research tools, Therapeutics & prevention, Nanotechnology, Diagnostic technology
Hyaluronic Acid Based Nanogel or Microgel Compositions for Targeted Delivery of Small Molecule Therapeutics
Published: 9/13/2019   |   Inventor(s): Sankaran Thayumanavan, Lisa Minter
Category(s): Biotechnology, Diagnostic technology, Healthcare, Life Sciences, Nanotechnology, Research tools, Therapeutics & prevention
Enhanced Charge Transport Through Nanoconfinement
A team of accomplished researchers at the University of Massachusetts Amherst has discovered a novel pathway for enhancing anhydrous proton transport in polymeric materials. This pathway entails generating supramolecular nanoscale confinement in polymers containing anhydrous proton transport functionalities. By carefully designing the polymer structures, the proton transport moieties of the polymers can be confined and organized within the nanoscale domains of the polymers via self-assembly, resulting in enhanced proton transport capabilities. This enhancement improves the conductivity of the polymers by 2-3 orders of magnitude. The high conductivities observed for the polymers with nanoconfinements are correlated with their ability to form locally high concentrations of proton transport moieties. These polymers allow high conductivities at high temperatures, which can increase fuel cell efficiency, lower cost, simplify heat management, and provide better tolerance of the fuel cell catalysts against poisoning.
Published: 11/19/2014   |   Inventor(s): Sankaran Thayumanavan, Mark Thomas Tuominen, Ryan Hayward
Category(s): Material science, Nanotechnology, Physical Science, Devices, Clean Energy
Novel Amphiphilic Polymers for Selective Extraction and Highly Enhanced MALDI-MS Analysis of Peptides
Dr. Sankaran Thayumanavan has developed novel amphiphilic polymers capable of forming self-assembled micelle and reverse-micelle type nanostructures. These amphiphilic polymers can be used to selectively extract and enrich peptides from complex mixtures for highly enhanced analysis by matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS). The selectivity of peptide extraction is based on the difference in isoelectric points of the peptide analytes. When peptides are extracted by the amphiphilic polymers and detected by MALDI-MS in the presence of the polymers, peptide-ion signals can be enhanced by 3-5 orders of magnitude. This enormous signal enhancement enables the MALDI-MS analysis of peptides present at very low concentrations and protein digests of highly complex biological samples.
Published: 11/18/2014   |   Inventor(s): Sankaran Thayumanavan
Category(s): Research tools, Biotechnology
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