Novel Protein-Polymer Nanoassemblies for the Intracellular Delivery and Stimuli-responsive Traceless Release of Proteins
S. Thai Thayumanavan, Ph.D.
- Novel protein-polymer conjugates as prodrugs
- Therapeutic protein-polymer conjugation kits
- Reversible and ultrafast click reaction between surface modified protein and synthetic polymer, enabling efficient protein encapsulation and triggered intracellular release
- Versatile linker chemistry allowing for traceless protein release in its native form in response to different types of intracellular stimuli, such as a change in pH, reducing conditions or concentration of reactive oxygen species
- Applicable to encapsulation and delivery of proteins of different sizes and isoelectric points
This invention provides a new intracellular protein delivery strategy that involves introducing ultrafast click reaction moieties into a therapeutic protein and a synthetic polymer to allow for the formation of protein-polymer nanoassemblies that are capable of releasing encapsulated protein in its native form in response to an intracellular trigger.
Dr. Thayumanavan is a Professor in the Department of Chemistry. He is a highly accomplished expert in organic and polymer chemistry and a prolific inventor. His research focuses on the design, synthesis and characterization of organic macromolecules of interest in supramolecular chemistry, materials science and biological applications. Dr. Thayumanavan has broad and well-established expertise in developing custom-designed molecules for specific end-use applications such as pharmaceutical delivery, smart sensors, and fuel cells.
Available for Licensing and/or Sponsored Research
UMA 20-001
Patent Issued
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