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Microfluidic Devices with Graphene Electrodes
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Published: 3/1/2024   |   Inventor(s): Sarah Perry, Shuo Sui
Category(s): Devices, Engineering, Material science, Research tools
Flow Sensor Based on Coulometric Interrogation of a Graphene Microelectrode
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Published: 3/1/2024   |   Inventor(s): Jinglei Ping, Xiaoyu Zhang
Category(s): Devices & sensors, Engineering, Healthcare, Life Sciences, Research tools, Electronics
Katsumata / Vinyl-Comonomer Additive for Radically Activated Dynamic Phenomena
                                            
Published: 2/8/2024   |   Inventor(s): Reika Katsumata, Autumn Mineo
Category(s): Chemicals, Engineering, Material science, Physical Science, Research tools
Nanopore Tweezer System for Protein Kinase Allosteric Drug Screening
Protein kinases are enzymes that catalyze the phosphorylation of substrate proteins, regulating a wide range of cellular pathways. Aberrant kinase activities are implicated in various human diseases, making the kinases essential drug targets. This invention provides a nanopore-tweezer-based compound screening platform for the identification of allosteric drugs that can bind to allosteric sites on protein kinases and overcome drug resistance.
Published: 8/3/2023   |   Inventor(s): Min Chen, Fanjun Li
Category(s): Biotechnology, Life Sciences, Research tools
Cell-Membrane-Coated Polymeric Nanoparticles for Selective Intracellular Delivery of Therapeutics
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Published: 8/10/2023   |   Inventor(s): Sankaran Thayumanavan
Category(s): Healthcare, Life Sciences, Biotechnology, Nanotechnology, Therapeutics & prevention, Research tools
Nanopore-based Sensors for Antibody Screening Applications
This invention provides OmpG nanopore-based sensors for antibody screening applications. Each OmpG nanopore is engineered to contain a heterologous peptide sequence in one or more flexible loops of the nanopore, allowing for target-specific binding and detection.
Published: 6/26/2023   |   Inventor(s): Min Chen, Joshua Foster, Minji Kim, Matthew Moore
Category(s): Devices & sensors, Life Sciences, Research tools
Novel Ferroptosis Inducing Compounds as Anti-cancer Agents
Ferroptosis is a well-defined cell death mechanism distinct from other regulated cell death phenotypes such as apoptosis, necrosis and autophagy. This invention provides novel ferroptosis inducer compounds that represent a new class of highly specific chemotherapeutic agents.
Published: 8/10/2023   |   Inventor(s): Rachid Skouta, Thomas Dawson, Rohit Bhadoria
Category(s): Chemicals, Healthcare, Life Sciences, Research tools, Therapeutics & prevention
Demineralized Bone Paper and Applications Thereof
This invention provides structurally well-defined, three-dimensional bone tissue grafts produced from stacked demineralized bone paper (DBP), methods for treating a subject using such bone tissue grafts, methods for making DBP, and in vitro assay systems and methods for assaying the effect of an agent on bone development or health.
Published: 8/10/2023   |   Inventor(s): Jungwoo Lee, Jae-Hyuck Shim, Ryan Carpenter, Yongkuk Park, Jun-Goo Kwak
Category(s): Biotechnology, Devices, Healthcare, Life Sciences, Research tools, Therapeutics & prevention
Economical Surface Treatment for Harvesting Epithelial Cells from Biological Fluids
This invention provides economical, bio-interactive surfaces and surface treatment methods for selective capture of targeted epithelial cells or other cell types from cell mixtures or complex biological fluids. Preparation or fabrication of the engineered surfaces provided by this technology does not require the use of expensive and unstable biomolecular materials, and the resulting surfaces can distinguish different cell types or cells that express different levels of the same surface adhesion marker. Such engineered surfaces can be used as economical tools for assessment of cancer risk, cancer diagnosis, and tracking of the effectiveness of cancer treatments, among other potential applications.
Published: 8/10/2023   |   Inventor(s): Maria Santore, Kathleen Arcaro, Surachate Kalasin
Category(s): Biotechnology, Nanotechnology, Diagnostic technology, Devices & sensors, Life Sciences, Healthcare, Research tools
RigNet: Neural Rigging for Articulated Characters
Character rigging is the process where animators fit a skeleton to a 3D model, which then allows the animators to manipulate the movement of, or animate, the model. Currently, animators must manually define the skeleton’s joints, how they’re connected, and how the model’s body parts move. This is a very time intensive process that can take hours or days just for a single character. With the rapid rise in need for animation-ready characters and avatars in the areas of games, films, mixed reality and social media, character rigging is presently a major bottleneck to scaling the creation of animated characters.

 

In this work, the authors have written software called RigNet, which is an end-to-end automated method for producing animation rigs from input character models. By automating character rigging through RigNet, the character rigging process time is reduced from hours to minutes. RigNet is based on a deep learning architecture, trained on a large and diverse collection of rigged models, including their mesh, skeletons and corresponding skin weights. RigNet is able to predict both a unique skeleton and a skinning that match animator expectations, which is in contrast to prior art methods that just fit pre-defined, template skeletons to the 3D models that aren’t high enough quality. Finally, because all that is needed to use RigNet is a 3D model, animators do not need to be trained experts to rig characters, as is the case today.

Published: 2/17/2023   |   Inventor(s): Evangelos Kalogerakis, Zhan Xu, Yang Zhou
Category(s): Software & information technology, Research tools, Computers, Communications & internet
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