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Economical Surface Treatment for Harvesting Epithelial Cells from Biological Fluids
This invention provides economical, bio-interactive surfaces and surface treatment methods for selective capture of targeted epithelial cells or other cell types from cell mixtures or complex biological fluids. Preparation or fabrication of the engineered surfaces provided by this technology does not require the use of expensive and unstable biomolecular materials, and the resulting surfaces can distinguish different cell types or cells that express different levels of the same surface adhesion marker. Such engineered surfaces can be used as economical tools for assessment of cancer risk, cancer diagnosis, and tracking of the effectiveness of cancer treatments, among other potential applications.
Published: 6/11/2021   |   Inventor(s): Maria Santore, Kathleen Arcaro, Surachate Kalasin
Category(s): Biotechnology, Nanotechnology, Diagnostic technology, Devices & sensors, Life Sciences, Healthcare, Research tools
Polymeric Nanogles for the Encapsulation, Delivery and pH-Triggered Release of Proteins
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Published: 6/11/2021   |   Inventor(s): Sankaran Thayumanavan, Mijanur Molla, Scott Garman
Category(s): Biotechnology, Diagnostic technology, Healthcare, Life Sciences, Nanotechnology, Research tools
Miniaturized, Cost-Effective Biosensing Devices for Point-of-Care and Therapeutic Screening Applications
This invention provides miniaturized and portable biosensing devices that employ novel spectrally-filtered photodiode pairs and on-chip ratiometric sensing. The biosensing devices allow for rapid, high-precision detection of biomolecules of interest, and can be used for point-of-care and therapeutic screening applications.
Published: 5/7/2021   |   Inventor(s): Guangyu Xu
Category(s): Biotechnology, Devices, Devices & sensors, Diagnostic technology, Healthcare, Life Sciences, Engineering, Research tools
Rapid Detection of Penetration of Pesticides, Antibiotices or Other Analytes in Plants and Produce
This invention provides a simple and rapid method for measuring pesticide and/or antibiotic penetration into plants and produce. The method involves the use of surface-enhanced Raman scattering (SERS) mapping for in situ and real-time tracking of the analytes by using metallic nanoparticles as probes.
Published: 5/7/2021   |   Inventor(s): Lili He
Category(s): Environmental, Food technology & plant science, Nanotechnology, Research tools
An Ex Vivo Method of Generating Super Regulatory T Cells as a Cell-based Therapy for the Prevention of Graft-vs-Host Disease
Regulatory T cells maintain immunological tolerance and dampen inflammatory responses. Administering regulatory T cells can prevent the immune-mediated tissue destruction of graft-versus-host disease, which frequently accompanies hematopoietic stem cell transfer. This technology provides a simple and effective method to generate and expand a unique population of stable and highly suppressive regulatory T cells, which can be used as a cell-based therapy for the prevention of graft-versus-host disease.
Published: 1/28/2021   |   Inventor(s): Lisa Minter, Gregory Tew, Emrah Ozay
Category(s): Biotechnology, Healthcare, Life Sciences, Research tools, Therapeutics & prevention
Novel Protein-Polymer Nanoassemblies for the Intracellular Delivery and Stimuli-responsive Traceless Release of Proteins
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Published: 12/24/2019   |   Inventor(s): Sankaran Thayumanavan, Bin Liu
Category(s): Biotechnology, Healthcare, Life Sciences, Nanotechnology, Research tools
Novel Chemical Reagents for Antibody-Drug Conjugation, Protein Delivery, and Traceless Release
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Published: 12/23/2019   |   Inventor(s): Sankaran Thayumanavan, Jiaming Zhuang
Category(s): Biotechnology, Life Sciences, Research tools
New Protein Labeling Reagents for Improved Protein Structural Analysis by Mass Spectrometry
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Published: 12/23/2019   |   Inventor(s): Richard Vachet, Sankaran Thayumanavan, Bo Zhao, Jiaming Zhuang
Category(s): Chemicals, Life Sciences, Research tools
Novel Polymeric Nanogels for Controlled Intracellular Protein Delivery and Traceless Release
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Published: 9/18/2019   |   Inventor(s): Sankaran Thayumanavan, Jiaming Zhuang
Category(s): Life Sciences, Biotechnology, Healthcare, Research tools, Therapeutics & prevention, Nanotechnology, Diagnostic technology
On-body Sensing of Cocaine Craving, Euphoria and Drug-Seeking Behavior
Illicit drug use, such as cocaine, imposes an enormous financial burden on the U.S. healthcare system, more than $600 billion annually. Better treatments are desperately sought, and important in that search is a better understanding of the factors influencing drug use: drug craving, drug-seeking behavior, and drug-induced euphoria. Wearable mobile health technologies open the door to continuous monitoring of drug users, providing a wealth of valuable data compared to current brief, in-person appointments of addicts at clinics. While other studies have examined modeling addiction with wearable health monitors for other substances or in animals, none have done so for cocaine addiction in humans.

 

Here, the inventors have developed a machine learning model based on ECG and respiratory data, common measurables in commercially available wearable chest bands, that can, for the first time, predict cocaine craving, euphoria, and drug-seeking behavior in humans. With the ability to predict these various addiction states, just-in-time interventions for cocaine addicts become possible.

Published: 9/17/2019   |   Inventor(s): Deepak Ganesan, Tauhidur Rahman, Bhanu Teja Gullapalli, Gustavo Angarita, Robert Malison
Category(s): Devices & sensors, Healthcare, Research tools
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