Let-7 promotes superior anti-tumor activity of CD8 T cells and memory formation

LEAD INVENTOR:

Leonid Pobezinsky, Ph.D.

 

PRODUCT OPPORTUNITIES

• • Improve T-cell therapies

 

COMPETITIVE ADVANTAGES

• • Improve cancer immunotherapies that are based on adoptive T cell transfer/ improves T-cell therapies

 

TECHNOLOGY DESCRIPTION

This invention demonstrates that let-7 miRNA  regulates T cell responses and offers a strategy in developing next-generation immunotherapies by preserving the multipotency of effector cells rather than enhancing the efficacy of differentiation.

 

 

ABOUT THE INVENTOR

Prof. Leonid Pobezinsky is a professor in the Department of Veterinary and Animal Sciences at the University of Massachusetts Amherst. His research interests lie in the molecular mechanisms that control differentiation and transformation programs within an organism’s immune system.

 

 

AVAILABILITY:

Available for Licensing and/or Sponsored Research

DOCKET:

UMA 18-067

PATENT STATUS:

Patent Pending