Polymeric Nanoparticle-Based Antibiofilm Therapy
Vincent M. Rotello, Ph.D.
• Antimicrobial ointment for topical treatments
• Antimicrobial injectable for in vivo treatments
• Antibiofilm therapy
• Non-antibiotic based
• High efficacy against both planktonic bacteria and more drug-resistant bacterial biofilms
• Low toxicity towards mammalian cells
• Low-cost, environmentally friendly fabrication process for the active ingredient, which does not require the use of organic solvents or purification procedures
This invention provides a novel therapeutic platform to combat multidrug-resistant bacterial and biofilm infections using engineered polymeric nanoparticles. The polymeric nanoparticles can penetrate and eradicate pre-formed bacterial biofilms while maintaining high therapeutic indices. The nanoparticles are formed via self-assembly of engineered synthetic polymers in aqueous solutions, without the need to use any organic solvent or purification procedures.
Dr. Vincent Rotello is the Charles A. Goessmann Professor of Chemistry and a University Distinguished Professor at the University of Massachusetts Amherst. He is actively involved in the area of bionanotechnology, and his research includes programs in delivery, imaging, diagnostics and nanotoxicology.
Available for Licensing and/or Sponsored Research
UMA 16-071
Patent Issued
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