RENEWABLE SURFACES FOR CAPTURE, KILLING AND RELEASE OF BACTERIA
Maria M. Santore, Ph.D.
• Continuous monitoring, on-line sensors for bacteria in fluids • Non-leaching antibacterial surfaces, tubing and fittings for life sciences applications • Non-leaching antibacterial catheters • Whole-cell diagnostic surfaces that selectively capture bacterial targets
• Does not require toxic, leached agents, such as ionic silver, for bacterial killing • Does not require harsh/toxic chemicals for bacterial removal • Does not require multiple processing steps for surface regeneration • Can be engineered to selectively capture bacteria in the presence of proteins or to discriminate between different broad bacterial classes
This invention provides economical, renewable surfaces and related methods for selective capture of bacteria in a fluid medium and for killing and/or release of the captured bacteria. The fabrication of these surfaces or surface-treated substrate materials does not require the use of expensive biomolecules and toxic chemicals. The surfaces capture and kill bacteria on contact without leaching any toxic antimicrobial agents. The surfaces can rapidly release captured or killed bacteria via mechanical means, and thus are easily renewable for subsequent round of bacterial capture, killing and release, which makes them ideal for use in on-line bacterial sensor systems. In addition, the surfaces can be engineered to selectively capture bacteria from complex fluid media or selectively capture one bacterial strain over another.
Dr. Maria M. Santore is a Professor in the Department of Polymer Science and Engineering. Her research group creates new materials and methods for biomedical and other applications.
Available for Licensing and/or Sponsored Research
UMA 13-027
F
US Patent Issued: US 9,920,353
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