Decorating Microbially Produced Protein Nanowires with Peptide Ligands
This invention demonstrates the functionalization of electronically conductive protein nanowires (e-PNs) with one or more peptides (e.g. “His-tag” , “HA-tag”) while maintaining, or possibly increasing, their conductivity. The ability to decorate e-PNs greatly expand the potential application in electronic devices and for the fabrication of electrically conductive composite materials.
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Artificial Reproduction Technique
This invention provides a method to improve the functionality and/or fertility of sperm by subjecting the isolated sperm to a starvation protocol and/or ionophore. Said sperm can be used to increase artificial insemination by reducing the number of sperm needed as well as improving conception rates.
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Magnetohydrodynamic clearing and antibody staining
This invention provides devices and methods for the interrogation of molecular structure and function of virtually any biological tissue by allowing histological analyses of large biological tissues with numerous biomarkers (antibodies, RNAs, chemical labels). In addition, this technique maintains the integrity of large tissue samples making it possible to perform multiple rounds of histological staining to resolve 3-D organization of biological structures at the macroscopic and microscope scale.
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Let-7 promotes superior anti-tumor activity of CD8 T cells and memory formation
This invention demonstrates that let-7 miRNA regulates T cell responses and offers a strategy in developing next-generation immunotherapies by preserving the multipotency of effector cells rather than enhancing the efficacy of differentiation.
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Flow Sensor Based on Coulometric Interrogation of a Graphene Microelectrode
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Localization of Payload Delivery Systems to Tumor Sites via Beacon Cell Targeting
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Noncationic Nucleic Acid-Polymer Complexes for Nucleic Acid Delivery
This invention provides a new strategy for nucleic acid delivery by using novel cross-linkable and surface-charge modifiable synthetic polymers. The use of the novel polymer system allows for robust nuclecid-polymer complexation, easy removal of cationic moieties of the polymer and self-crosslinking of the polymer in a single step, and stimuli-responsive release of the nucleic acid molecules in the cell.
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Nanopore Tweezer System for Protein Kinase Allosteric Drug Screening
Protein kinases are enzymes that catalyze the phosphorylation of substrate proteins, regulating a wide range of cellular pathways. Aberrant kinase activities are implicated in various human diseases, making the kinases essential drug targets. This invention provides a nanopore-tweezer-based compound screening platform for the identification of allosteric drugs that can bind to allosteric sites on protein kinases and overcome drug resistance.
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Cell-Membrane-Coated Polymeric Nanoparticles for Selective Intracellular Delivery of Therapeutics
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Nanopore-based Sensors for Antibody Screening Applications
This invention provides OmpG nanopore-based sensors for antibody screening applications. Each OmpG nanopore is engineered to contain a heterologous peptide sequence in one or more flexible loops of the nanopore, allowing for target-specific binding and detection.
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